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Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man

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Standard

Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. / Waldemar, G; Schmidt, J F; Andersen, A R; Vorstrup, S; Ibsen, H; Paulson, O B.

I: Journal of Hypertension, Bind 7, Nr. 3, 03.1989, s. 229-35.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Waldemar, G, Schmidt, JF, Andersen, AR, Vorstrup, S, Ibsen, H & Paulson, OB 1989, 'Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man', Journal of Hypertension, bind 7, nr. 3, s. 229-35.

APA

Waldemar, G., Schmidt, J. F., Andersen, A. R., Vorstrup, S., Ibsen, H., & Paulson, O. B. (1989). Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. Journal of Hypertension, 7(3), 229-35.

Vancouver

Waldemar G, Schmidt JF, Andersen AR, Vorstrup S, Ibsen H, Paulson OB. Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. Journal of Hypertension. 1989 mar;7(3):229-35.

Author

Waldemar, G ; Schmidt, J F ; Andersen, A R ; Vorstrup, S ; Ibsen, H ; Paulson, O B. / Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. I: Journal of Hypertension. 1989 ; Bind 7, Nr. 3. s. 229-35.

Bibtex

@article{160e905fa21248e0aec7c507c1740d5a,
title = "Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man",
abstract = "The acute effect on the lower limit of cerebral blood flow (CBF) autoregulation of an angiotensin converting enzyme (ACE) inhibitor, captopril, was studied in normotensive volunteers and in hypertensive patients. Baseline CBF was measured using xenon-133 inhalation tomography, and changes in CBF were measured using the arterio-venous oxygen difference method. Cerebral blood flow autoregulation was studied in two separate normotensive groups, one group of 12 volunteers serving as a control, and one group of 12 volunteers studied after the administration of captopril 50 mg. In a group of seven hypertensive patients CBF autoregulation was studied before and 1 h after the administration of captopril 25 mg. In the normotensive volunteers the median lower limit of CBF autoregulation was 83 and 74 mmHg in the untreated and the captopril-treated group, respectively, with no significant difference between the two groups. In five of the hypertensive patients the lower limit of CBF autoregulation was lowered by captopril, in median by 22 mmHg. However, in two patients it was increased, by 3 and 13 mmHg, respectively. It is proposed that the shift in the lower limit of CBF autoregulation seen in some of our cases, and which has previously been documented in experimental studies, may be dependent on the activity of the sympathetic nervous system.",
keywords = "Adult, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Captopril/pharmacology, Cerebrovascular Circulation/drug effects, Female, Homeostasis/drug effects, Humans, Hypertension/physiopathology, Male, Middle Aged, Peptidyl-Dipeptidase A/physiology",
author = "G Waldemar and Schmidt, {J F} and Andersen, {A R} and S Vorstrup and H Ibsen and Paulson, {O B}",
year = "1989",
month = mar,
language = "English",
volume = "7",
pages = "229--35",
journal = "Journal of Hypertension. Supplement",
issn = "0952-1178",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man

AU - Waldemar, G

AU - Schmidt, J F

AU - Andersen, A R

AU - Vorstrup, S

AU - Ibsen, H

AU - Paulson, O B

PY - 1989/3

Y1 - 1989/3

N2 - The acute effect on the lower limit of cerebral blood flow (CBF) autoregulation of an angiotensin converting enzyme (ACE) inhibitor, captopril, was studied in normotensive volunteers and in hypertensive patients. Baseline CBF was measured using xenon-133 inhalation tomography, and changes in CBF were measured using the arterio-venous oxygen difference method. Cerebral blood flow autoregulation was studied in two separate normotensive groups, one group of 12 volunteers serving as a control, and one group of 12 volunteers studied after the administration of captopril 50 mg. In a group of seven hypertensive patients CBF autoregulation was studied before and 1 h after the administration of captopril 25 mg. In the normotensive volunteers the median lower limit of CBF autoregulation was 83 and 74 mmHg in the untreated and the captopril-treated group, respectively, with no significant difference between the two groups. In five of the hypertensive patients the lower limit of CBF autoregulation was lowered by captopril, in median by 22 mmHg. However, in two patients it was increased, by 3 and 13 mmHg, respectively. It is proposed that the shift in the lower limit of CBF autoregulation seen in some of our cases, and which has previously been documented in experimental studies, may be dependent on the activity of the sympathetic nervous system.

AB - The acute effect on the lower limit of cerebral blood flow (CBF) autoregulation of an angiotensin converting enzyme (ACE) inhibitor, captopril, was studied in normotensive volunteers and in hypertensive patients. Baseline CBF was measured using xenon-133 inhalation tomography, and changes in CBF were measured using the arterio-venous oxygen difference method. Cerebral blood flow autoregulation was studied in two separate normotensive groups, one group of 12 volunteers serving as a control, and one group of 12 volunteers studied after the administration of captopril 50 mg. In a group of seven hypertensive patients CBF autoregulation was studied before and 1 h after the administration of captopril 25 mg. In the normotensive volunteers the median lower limit of CBF autoregulation was 83 and 74 mmHg in the untreated and the captopril-treated group, respectively, with no significant difference between the two groups. In five of the hypertensive patients the lower limit of CBF autoregulation was lowered by captopril, in median by 22 mmHg. However, in two patients it was increased, by 3 and 13 mmHg, respectively. It is proposed that the shift in the lower limit of CBF autoregulation seen in some of our cases, and which has previously been documented in experimental studies, may be dependent on the activity of the sympathetic nervous system.

KW - Adult

KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology

KW - Captopril/pharmacology

KW - Cerebrovascular Circulation/drug effects

KW - Female

KW - Homeostasis/drug effects

KW - Humans

KW - Hypertension/physiopathology

KW - Male

KW - Middle Aged

KW - Peptidyl-Dipeptidase A/physiology

M3 - Journal article

C2 - 2540235

VL - 7

SP - 229

EP - 235

JO - Journal of Hypertension. Supplement

JF - Journal of Hypertension. Supplement

SN - 0952-1178

IS - 3

ER -

ID: 275282046