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Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke

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Standard

Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. / Waldemar, G; Vorstrup, S; Andersen, A R; Pedersen, H; Paulson, O B.

I: Journal of Cardiovascular Pharmacology, Bind 14, Nr. 5, 11.1989, s. 722-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Waldemar, G, Vorstrup, S, Andersen, AR, Pedersen, H & Paulson, OB 1989, 'Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke', Journal of Cardiovascular Pharmacology, bind 14, nr. 5, s. 722-9. https://doi.org/10.1097/00005344-198911000-00008

APA

Waldemar, G., Vorstrup, S., Andersen, A. R., Pedersen, H., & Paulson, O. B. (1989). Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. Journal of Cardiovascular Pharmacology, 14(5), 722-9. https://doi.org/10.1097/00005344-198911000-00008

Vancouver

Waldemar G, Vorstrup S, Andersen AR, Pedersen H, Paulson OB. Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. Journal of Cardiovascular Pharmacology. 1989 nov;14(5):722-9. https://doi.org/10.1097/00005344-198911000-00008

Author

Waldemar, G ; Vorstrup, S ; Andersen, A R ; Pedersen, H ; Paulson, O B. / Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. I: Journal of Cardiovascular Pharmacology. 1989 ; Bind 14, Nr. 5. s. 722-9.

Bibtex

@article{ce8048e54c884f8ebbfcb826fba13e16,
title = "Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke",
abstract = "The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.",
keywords = "Acute Disease, Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Blood Pressure/drug effects, Captopril/pharmacology, Cerebrovascular Circulation/drug effects, Cerebrovascular Disorders/diagnostic imaging, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Xenon Radioisotopes",
author = "G Waldemar and S Vorstrup and Andersen, {A R} and H Pedersen and Paulson, {O B}",
year = "1989",
month = nov,
doi = "10.1097/00005344-198911000-00008",
language = "English",
volume = "14",
pages = "722--9",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke

AU - Waldemar, G

AU - Vorstrup, S

AU - Andersen, A R

AU - Pedersen, H

AU - Paulson, O B

PY - 1989/11

Y1 - 1989/11

N2 - The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.

AB - The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.

KW - Acute Disease

KW - Aged

KW - Aged, 80 and over

KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology

KW - Blood Pressure/drug effects

KW - Captopril/pharmacology

KW - Cerebrovascular Circulation/drug effects

KW - Cerebrovascular Disorders/diagnostic imaging

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Tomography, Emission-Computed

KW - Xenon Radioisotopes

U2 - 10.1097/00005344-198911000-00008

DO - 10.1097/00005344-198911000-00008

M3 - Journal article

C2 - 2481186

VL - 14

SP - 722

EP - 729

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 5

ER -

ID: 275282123