Forskning ved Københavns Universitet - Københavns Universitet

Forside

Antibody to histo-blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or O donors.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  • M Arendrup
  • J E Hansen
  • H Clausen
  • C Nielsen
  • Lars Reinhardt Mathiesen
  • Jens Ole Nielsen
Three virus isolates HTLV-IIIB/lyA, HTLV-IIIB/lyB and HTLV-IIIB/lyO, obtained by passaging and propagating the HTLV-IIIB/H9 isolate in three separate cultures of mixed peripheral blood mononuclear cells (PBMC) from donors of blood type A, B or O, respectively, were tested for susceptibility for virus neutralization by the monoclonal antibody (MAb) AH16 directed against the blood group A epitope. MAb AH16 was previously shown to inhibit cell-free virus infection using HTLV-IIIB propagated in H9 cells. AH16 showed a concentration-dependent inhibition of the HTLV-IIIB/lyA isolate but did not inhibit the HTLV-IIIB/lyB or the HTLV-IIIB/lyO isolate. Specificity of the MAb-mediated inhibition was shown using A-antigen (tetrasaccharide). Thus, HIV infection of PBMC from donors with blood type A appears to induce expression of host-cell-encoded carbohydrate blood group A epitope on HIV which can be a target for MAb-mediated virus neutralization.
OriginalsprogEngelsk
TidsskriftAIDS
Vol/bind5
Udgave nummer4
Sider (fra-til)441-444
Antal sider4
ISSN0269-9370
StatusUdgivet - 1991

ID: 34125214