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Are microRNAs located in genomic regions associated with cancer?

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • P. Lamy
  • C. L. Andersen
  • L. Dyrskjøt
  • N. Tørring
  • T. Ørntoft
  • Wiuf, Carsten

We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind95
Udgave nummer10
Sider (fra-til)1415-1418
Antal sider4
ISSN0007-0920
DOI
StatusUdgivet - 20 nov. 2006
Eksternt udgivetJa

ID: 203903795