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Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells

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Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.
OriginalsprogEngelsk
TidsskriftF E B S Letters
Vol/bind218
Udgave nummer1
Sider (fra-til)93-96
Antal sider4
ISSN0014-5793
StatusUdgivet - 1 jan. 1987

ID: 45562649