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Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers

Publikation: Forskning - peer reviewTidsskriftartikel

L L Thomsen, Helle Klingenberg Iversen, T A Brinck, J Olesen

The sensitivity to nitroglycerin-induced dilatation of large intracranial arteries was studied in 17 patients with migraine without aura, 17 age and sex-matched healthy subjects and 9 patients with episodic tension-type headache. Nitroglycerin in the doses of 0.015, 0.03, 0.25 microgram/kg/min was successively infused for 15 min per dose. Blood velocity (Vmean) in the middle cerebral artery (MCA) was recorded with transcranial Doppler before and at the end of every infusion period, and 30 and 60 min after end of the last infusion. In all three groups Vmean decreased with increasing doses (p < 0.001). The response was more pronounced in migraine patients at the two higher doses (p < 0.05). Since nitroglycerin acts as an exogenous source of nitric oxide (NO), these data support that NO supersensitivity may be an important molecular mechanism of migraine pain.

OriginalsprogEngelsk
TidsskriftCephalalgia : an international journal of headache
Vol/bind13
Tidsskriftsnummer6
Sider (fra-til)395-9; discussion 376
ISSN0333-1024
StatusUdgivet - dec. 1993

ID: 128984494