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"Artifactual" arsenate DNA

Publikation: Bidrag til tidsskriftTidsskriftartikel

The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual.
OriginalsprogEngelsk
TidsskriftArtificial DNA
Vol/bind3
Udgave nummer1
Sider (fra-til)1-2
Antal sider2
ISSN1949-095X
DOI
StatusUdgivet - jan. 2012

ID: 38424602