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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Elizabeth K Speliotes
  • Cristen J Willer
  • Sonja I Berndt
  • Keri L Monda
  • Gudmar Thorleifsson
  • Anne U Jackson
  • Hana Lango Allen
  • Cecilia M Lindgren
  • Jian'an Luan
  • Reedik Mägi
  • Joshua C Randall
  • Sailaja Vedantam
  • Thomas W Winkler
  • Qi Lu
  • Tsegaselassie Workalemahu
  • Iris M Heid
  • Valgerdur Steinthorsdottir
  • Heather M Stringham
  • Michael N Weedon
  • Eleanor Wheeler
  • Andrew R Wood
  • Teresa Ferreira
  • Robert J Weyant
  • Ayellet V Segrè
  • Karol Estrada
  • Liming Liang
  • James Nemesh
  • Ju-Hyun Park
  • Stefan Gustafsson
  • Oskari Kilpeläinen, Tuomas
  • Jian Yang
  • Nabila Bouatia-Naji
  • Tõnu Esko
  • Mary F Feitosa
  • Zoltán Kutalik
  • Massimo Mangino
  • Soumya Raychaudhuri
  • Andre Scherag
  • Albert Vernon Smith
  • Ryan Welch
  • Jing Hua Zhao
  • Katja K Aben
  • Devin M Absher
  • Najaf Amin
  • Anna L Dixon
  • Gjesing, Anette Marianne Prior
  • Torben Jørgensen
  • Daniel R Witte
  • Hansen, Torben
  • Pedersen, Oluf Borbye
  • MAGIC
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P <5 × 10¿8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind42
Udgave nummer11
Sider (fra-til)937-48
Antal sider12
ISSN1061-4036
DOI
StatusUdgivet - 1 nov. 2010

ID: 33497211