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Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
OriginalsprogEngelsk
TidsskriftInternational Journal of Immunogenetics (Print Edition)
Vol/bind34
Udgave nummer3
Sider (fra-til)149-51
Antal sider3
ISSN1744-3121
DOI
StatusUdgivet - 2007

ID: 43535286