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Association between vitamin K-1 intake and mortality in the Danish Diet, Cancer, and Health cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Claire R. Palmer
  • Jamie W. Bellinge
  • Frederik Dalgaard
  • Marc Sim
  • Kevin Murray
  • Emma Connolly
  • Lauren C. Blekkenhorst
  • Catherine P. Bondonno
  • Kevin D. Croft
  • Gislason, Gunnar Hilmar
  • Tjønneland, Anne
  • Kim Overvad
  • Carl Schultz
  • Joshua R. Lewis
  • Jonathan M. Hodgson
  • Nicola P. Bondonno

Reported associations between vitamin K-1 and both all-cause and cause-specific mortality are conflicting. The 56,048 participants from the Danish Diet, Cancer, and Health prospective cohort study, with a median [IQR] age of 56 [52-60] years at entry and of whom 47.6% male, were followed for 23 years, with 14,083 reported deaths. Of these, 5015 deaths were CVD-related, and 6342 deaths were cancer-related. Intake of vitamin K-1 (phylloquinone) was estimated from a food-frequency questionnaire (FFQ), and its relationship with mortality outcomes was investigated using Cox proportional hazards models. A moderate to high (87-192 mu g/d) intake of vitamin K-1 was associated with a lower risk of all-cause [HR (95%CI) for quintile 5 vs quintile 1: 0.76 (0.72, 0.79)], cardiovascular disease (CVD)-related [quintile 5 vs quintile 1: 0.72 (0.66, 0.79)], and cancer-related mortality [quintile 5 vs quintile 1: 0.80 (0.75, 0.86)], after adjusting for demographic and lifestyle confounders. The association between vitamin K-1 intake and cardiovascular disease-related mortality was present in all subpopulations (categorised according to sex, smoking status, diabetes status, and hypertension status), while the association with cancer-related mortality was only present in current/former smokers (p for interaction = 0.002). These findings suggest that promoting adequate intakes of foods rich in vitamin K-1 may help to reduce all-cause, CVD-related, and cancer-related mortality at the population level.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind36
Sider (fra-til)1005–1014
Antal sider10
ISSN0393-2990
DOI
StatusUdgivet - 2021

ID: 281330319