Forskning ved Københavns Universitet - Københavns Universitet


Associations between baseline allergens and polysensitization

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • B.C. Carlsen
  • T. Menne
  • J.D. Johansen
Background: Identification of patients at risk of developing polysensitization is not possible at present. An association between weak sensitizers and polysensitization has been hypothesized. Objectives: To examine associations of 21 allergens in the European baseline series to polysensitization. Patients/Methods: From a database-based study with 14 998 patients patch tested with the European baseline series between 1985 and 2005, a group of 759 (5.1%) patients were polysensitized. Odds ratios were calculated to determine the relative contribution of each allergen to polysensitization. Results: Seven allergens - parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies. Conclusions: No common denominator for the association between the allergens and the polysensitization was apparent, and any association, whether positive or negative, was relatively low. Based on these results, sensitization to specific baseline allergens cannot be used as risk indicators for polysensitization
Udgivelsesdato: 2008
TidsskriftContact Dermatitis
Udgave nummer2
Sider (fra-til)96-102
Antal sider6
StatusUdgivet - 2008

Bibliografisk note

Times Cited: 0ArticleEnglishCarlsen, B. CCopenhagen Univ Hosp Gentofte, Natl Allergy Res Ctr, Dept Dermatol & Allergol, Ledreborg Alle 40,1, DK-2820 Gentofte, DenmarkCited References Count: 24331BMBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD

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