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Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients. / Kruiper, Caitlyn; Fagerlund, Birgitte; Nielsen, Mette O.; Düring, Signe; Jensen, Maria H.; Ebdrup, Bjorn H.; Glenthoj, Birte Y.; Oranje, Bob.

I: Psychological Medicine, Bind 49, Nr. 5, 2019, s. 868-875.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kruiper, C, Fagerlund, B, Nielsen, MO, Düring, S, Jensen, MH, Ebdrup, BH, Glenthoj, BY & Oranje, B 2019, 'Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients', Psychological Medicine, bind 49, nr. 5, s. 868-875. https://doi.org/10.1017/S0033291718001575

APA

Kruiper, C., Fagerlund, B., Nielsen, M. O., Düring, S., Jensen, M. H., Ebdrup, B. H., ... Oranje, B. (2019). Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients. Psychological Medicine, 49(5), 868-875. https://doi.org/10.1017/S0033291718001575

Vancouver

Kruiper C, Fagerlund B, Nielsen MO, Düring S, Jensen MH, Ebdrup BH o.a. Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients. Psychological Medicine. 2019;49(5):868-875. https://doi.org/10.1017/S0033291718001575

Author

Kruiper, Caitlyn ; Fagerlund, Birgitte ; Nielsen, Mette O. ; Düring, Signe ; Jensen, Maria H. ; Ebdrup, Bjorn H. ; Glenthoj, Birte Y. ; Oranje, Bob. / Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients. I: Psychological Medicine. 2019 ; Bind 49, Nr. 5. s. 868-875.

Bibtex

@article{6c89622cfe1d4d01b045b013c9ac55f1,
title = "Associations between P3a and P3b amplitudes and cognition in antipsychotic-na{\"i}ve first-episode schizophrenia patients",
abstract = "Background Cognitive deficits are already present in early stages of schizophrenia. P3a and P3b event-related potentials (ERPs) are believed to underlie the processes of attention and working memory (WM), yet limited research has been performed on the associations between these parameters. Therefore, we explored possible associations between P3a/b amplitudes and cognition in a large cohort of antipsychotic-na{\"i}ve, first-episode schizophrenia (AN-FES) patients and healthy controls (HC).Methods Seventy-three AN-FES patients and 93 age-A nd gender-matched HC were assessed for their P3a/b amplitude with an auditory oddball paradigm. In addition, subjects performed several subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).Results AN-FES patients had significantly reduced P3a/b amplitudes, as well as significantly lower scores on all cognitive tests compared with HC. Total group correlations revealed positive associations between P3b amplitude and WM and sustained attention and negative associations with all reaction time measures. These associations appeared mainly driven by AN-FES patients, where we found a similar pattern. No significant associations were found between P3b amplitude and cognitive measures in our HC. P3a amplitude did not correlate significantly with any cognitive measures in either group, nor when combined.Conclusions Our results provide further evidence for P3a/b amplitude deficits and cognitive deficits in AN-FES patients, which are neither due to antipsychotics nor to disease progress. Furthermore, our data showed significant, yet weak associations between P3b and cognition. Therefore, our data do not supply evidence for deficient P3a/b amplitudes as direct underlying factors for cognitive deficits in schizophrenia.",
keywords = "Antipsychotic-na{\"i}ve, Attention, Cognition, First-episode schizophrenia, P3a amplitude, P3b amplitude, Psychophysiology, Working memory",
author = "Caitlyn Kruiper and Birgitte Fagerlund and Nielsen, {Mette O.} and Signe D{\"u}ring and Jensen, {Maria H.} and Ebdrup, {Bjorn H.} and Glenthoj, {Birte Y.} and Bob Oranje",
year = "2019",
doi = "10.1017/S0033291718001575",
language = "English",
volume = "49",
pages = "868--875",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

AU - Kruiper, Caitlyn

AU - Fagerlund, Birgitte

AU - Nielsen, Mette O.

AU - Düring, Signe

AU - Jensen, Maria H.

AU - Ebdrup, Bjorn H.

AU - Glenthoj, Birte Y.

AU - Oranje, Bob

PY - 2019

Y1 - 2019

N2 - Background Cognitive deficits are already present in early stages of schizophrenia. P3a and P3b event-related potentials (ERPs) are believed to underlie the processes of attention and working memory (WM), yet limited research has been performed on the associations between these parameters. Therefore, we explored possible associations between P3a/b amplitudes and cognition in a large cohort of antipsychotic-naïve, first-episode schizophrenia (AN-FES) patients and healthy controls (HC).Methods Seventy-three AN-FES patients and 93 age-A nd gender-matched HC were assessed for their P3a/b amplitude with an auditory oddball paradigm. In addition, subjects performed several subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).Results AN-FES patients had significantly reduced P3a/b amplitudes, as well as significantly lower scores on all cognitive tests compared with HC. Total group correlations revealed positive associations between P3b amplitude and WM and sustained attention and negative associations with all reaction time measures. These associations appeared mainly driven by AN-FES patients, where we found a similar pattern. No significant associations were found between P3b amplitude and cognitive measures in our HC. P3a amplitude did not correlate significantly with any cognitive measures in either group, nor when combined.Conclusions Our results provide further evidence for P3a/b amplitude deficits and cognitive deficits in AN-FES patients, which are neither due to antipsychotics nor to disease progress. Furthermore, our data showed significant, yet weak associations between P3b and cognition. Therefore, our data do not supply evidence for deficient P3a/b amplitudes as direct underlying factors for cognitive deficits in schizophrenia.

AB - Background Cognitive deficits are already present in early stages of schizophrenia. P3a and P3b event-related potentials (ERPs) are believed to underlie the processes of attention and working memory (WM), yet limited research has been performed on the associations between these parameters. Therefore, we explored possible associations between P3a/b amplitudes and cognition in a large cohort of antipsychotic-naïve, first-episode schizophrenia (AN-FES) patients and healthy controls (HC).Methods Seventy-three AN-FES patients and 93 age-A nd gender-matched HC were assessed for their P3a/b amplitude with an auditory oddball paradigm. In addition, subjects performed several subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).Results AN-FES patients had significantly reduced P3a/b amplitudes, as well as significantly lower scores on all cognitive tests compared with HC. Total group correlations revealed positive associations between P3b amplitude and WM and sustained attention and negative associations with all reaction time measures. These associations appeared mainly driven by AN-FES patients, where we found a similar pattern. No significant associations were found between P3b amplitude and cognitive measures in our HC. P3a amplitude did not correlate significantly with any cognitive measures in either group, nor when combined.Conclusions Our results provide further evidence for P3a/b amplitude deficits and cognitive deficits in AN-FES patients, which are neither due to antipsychotics nor to disease progress. Furthermore, our data showed significant, yet weak associations between P3b and cognition. Therefore, our data do not supply evidence for deficient P3a/b amplitudes as direct underlying factors for cognitive deficits in schizophrenia.

KW - Antipsychotic-naïve

KW - Attention

KW - Cognition

KW - First-episode schizophrenia

KW - P3a amplitude

KW - P3b amplitude

KW - Psychophysiology

KW - Working memory

U2 - 10.1017/S0033291718001575

DO - 10.1017/S0033291718001575

M3 - Journal article

C2 - 29914589

AN - SCOPUS:85048838866

VL - 49

SP - 868

EP - 875

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 5

ER -

ID: 215512663