Forskning ved Københavns Universitet - Københavns Universitet

Forside

AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica

OriginalsprogEngelsk
TidsskriftActa Pathologica Microbiologica Scandinavica Section C Immunology
Vol/bind89 C
Udgave nummer1-6
Sider (fra-til)111-114
Antal sider4
ISSN0304-1328
DOI
StatusUdgivet - 1 jan. 1981

ID: 203862554