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Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial) : 3-years follow-up results. / Qayyum, Abbas Ali; Mathiasen, Anders Bruun; Helqvist, Steffen; Jørgensen, Erik; Haack-Sørensen, Mandana; Ekblond, Annette; Kastrup, Jens.

I: Journal of Translational Medicine, Bind 17, 360, 11.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Qayyum, AA, Mathiasen, AB, Helqvist, S, Jørgensen, E, Haack-Sørensen, M, Ekblond, A & Kastrup, J 2019, 'Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results', Journal of Translational Medicine, bind 17, 360. https://doi.org/10.1186/s12967-019-2110-1

APA

Qayyum, A. A., Mathiasen, A. B., Helqvist, S., Jørgensen, E., Haack-Sørensen, M., Ekblond, A., & Kastrup, J. (2019). Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results. Journal of Translational Medicine, 17, [360]. https://doi.org/10.1186/s12967-019-2110-1

Vancouver

Qayyum AA, Mathiasen AB, Helqvist S, Jørgensen E, Haack-Sørensen M, Ekblond A o.a. Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results. Journal of Translational Medicine. 2019 nov;17. 360. https://doi.org/10.1186/s12967-019-2110-1

Author

Qayyum, Abbas Ali ; Mathiasen, Anders Bruun ; Helqvist, Steffen ; Jørgensen, Erik ; Haack-Sørensen, Mandana ; Ekblond, Annette ; Kastrup, Jens. / Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial) : 3-years follow-up results. I: Journal of Translational Medicine. 2019 ; Bind 17.

Bibtex

@article{c8d91aadb0d248a79236fb8dd27cb4ad,
title = "Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results",
abstract = "Background: Stem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived stromal cells (ASCs) was studied in patients with refractory angina. Methods: Sixty patients with coronary artery stenosis and preserved left ventricular ejection fraction were 2:1 randomised to intramyocardial injections of ASCs or saline and followed for 3 years. Results: For patients in the ASC group, the bicycle exercise time and the exercise performance in watt were un-changed (383 ± 30 s to 370 ± 44 s, P = 0.052 and 81 ± 6 to 78 ± 10, P = 0.123, respectively), but the performance in METs was reduced significantly (4.2 ± 0.3 to 4.0 ± 0.4, P = 0.027) during the follow-up period. However, in the same period, there was in the placebo group a significant decline in bicycle exercise time (437 ± 53 s to 383 ± 58 s, P = 0.001), the exercise performance measured in watt (87 ± 12 W to 80 ± 12 W, P = 0.019) and in METs (4.5 ± 0.4 to 4.1 ± 0.4, P = 0.002). Moreover, angina measured as CCS class was significantly reduced in the ASC group but not in the placebo group (2.5 ± 0.9 to 1.8 ± 1.2, P = 0.002 and 2.5 ± 0.8 to 2.1 ± 1.3, P = 0.186, respectively). However, no significant change was observed between the two groups. Conclusions: Patients receiving ASCs had improved cardiac symptoms and unchanged exercise capacity, in opposition to deterioration in the placebo group. Trial registration ClinicalTrials.gov Identifier: NCT01449032. Registered 7 October 2011-Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT01449032 term=jens+kastrup&rank=7.",
keywords = "Adipose derived stromal cells, Chronic ischemic heart disease, Refractory angina, Regeneration, Stem cell therapy",
author = "Qayyum, {Abbas Ali} and Mathiasen, {Anders Bruun} and Steffen Helqvist and Erik J{\o}rgensen and Mandana Haack-S{\o}rensen and Annette Ekblond and Jens Kastrup",
year = "2019",
month = "11",
doi = "10.1186/s12967-019-2110-1",
language = "English",
volume = "17",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial)

T2 - 3-years follow-up results

AU - Qayyum, Abbas Ali

AU - Mathiasen, Anders Bruun

AU - Helqvist, Steffen

AU - Jørgensen, Erik

AU - Haack-Sørensen, Mandana

AU - Ekblond, Annette

AU - Kastrup, Jens

PY - 2019/11

Y1 - 2019/11

N2 - Background: Stem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived stromal cells (ASCs) was studied in patients with refractory angina. Methods: Sixty patients with coronary artery stenosis and preserved left ventricular ejection fraction were 2:1 randomised to intramyocardial injections of ASCs or saline and followed for 3 years. Results: For patients in the ASC group, the bicycle exercise time and the exercise performance in watt were un-changed (383 ± 30 s to 370 ± 44 s, P = 0.052 and 81 ± 6 to 78 ± 10, P = 0.123, respectively), but the performance in METs was reduced significantly (4.2 ± 0.3 to 4.0 ± 0.4, P = 0.027) during the follow-up period. However, in the same period, there was in the placebo group a significant decline in bicycle exercise time (437 ± 53 s to 383 ± 58 s, P = 0.001), the exercise performance measured in watt (87 ± 12 W to 80 ± 12 W, P = 0.019) and in METs (4.5 ± 0.4 to 4.1 ± 0.4, P = 0.002). Moreover, angina measured as CCS class was significantly reduced in the ASC group but not in the placebo group (2.5 ± 0.9 to 1.8 ± 1.2, P = 0.002 and 2.5 ± 0.8 to 2.1 ± 1.3, P = 0.186, respectively). However, no significant change was observed between the two groups. Conclusions: Patients receiving ASCs had improved cardiac symptoms and unchanged exercise capacity, in opposition to deterioration in the placebo group. Trial registration ClinicalTrials.gov Identifier: NCT01449032. Registered 7 October 2011-Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT01449032 term=jens+kastrup&rank=7.

AB - Background: Stem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived stromal cells (ASCs) was studied in patients with refractory angina. Methods: Sixty patients with coronary artery stenosis and preserved left ventricular ejection fraction were 2:1 randomised to intramyocardial injections of ASCs or saline and followed for 3 years. Results: For patients in the ASC group, the bicycle exercise time and the exercise performance in watt were un-changed (383 ± 30 s to 370 ± 44 s, P = 0.052 and 81 ± 6 to 78 ± 10, P = 0.123, respectively), but the performance in METs was reduced significantly (4.2 ± 0.3 to 4.0 ± 0.4, P = 0.027) during the follow-up period. However, in the same period, there was in the placebo group a significant decline in bicycle exercise time (437 ± 53 s to 383 ± 58 s, P = 0.001), the exercise performance measured in watt (87 ± 12 W to 80 ± 12 W, P = 0.019) and in METs (4.5 ± 0.4 to 4.1 ± 0.4, P = 0.002). Moreover, angina measured as CCS class was significantly reduced in the ASC group but not in the placebo group (2.5 ± 0.9 to 1.8 ± 1.2, P = 0.002 and 2.5 ± 0.8 to 2.1 ± 1.3, P = 0.186, respectively). However, no significant change was observed between the two groups. Conclusions: Patients receiving ASCs had improved cardiac symptoms and unchanged exercise capacity, in opposition to deterioration in the placebo group. Trial registration ClinicalTrials.gov Identifier: NCT01449032. Registered 7 October 2011-Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT01449032 term=jens+kastrup&rank=7.

KW - Adipose derived stromal cells

KW - Chronic ischemic heart disease

KW - Refractory angina

KW - Regeneration

KW - Stem cell therapy

U2 - 10.1186/s12967-019-2110-1

DO - 10.1186/s12967-019-2110-1

M3 - Journal article

C2 - 31711513

AN - SCOPUS:85074811860

VL - 17

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

M1 - 360

ER -

ID: 241361186