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Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Paul Farrow
  • Khodosevich, Konstantin
  • Yechiam Sapir
  • Anton Schulmann
  • Muhammad Aslam
  • Yael Stern-Bach
  • Hannah Monyer
  • Jakob von Engelhardt

AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins-namely CKAMP39, CKAMP52 and CKAMP59-that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.

OriginalsprogEngelsk
TidsskrifteLife
Vol/bind4
Sider (fra-til)e09693
ISSN2050-084X
DOI
StatusUdgivet - 1 dec. 2015
Eksternt udgivetJa

ID: 174655145