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Bacterial mitotic machineries

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Kenn Gerdes
  • Jakob Møller-Jensen
  • Gitte Ebersbach
  • Thomas Kruse
  • Kurt Nordström
  • Gitte Ebersbach Charbon
Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the ParM protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.
OriginalsprogEngelsk
TidsskriftCell
Vol/bind116
Udgave nummer3
Sider (fra-til)359-66
Antal sider8
ISSN0092-8674
StatusUdgivet - 6 feb. 2004

ID: 35161962