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Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

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  • Sherry A Castle
  • Elizabeth A Owuor
  • Stephanie H Thompson
  • Michelle R Garnsey
  • J Stacey Klutts
  • Tamara L Doering
  • Steven B Levery
The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.
OriginalsprogEngelsk
TidsskriftEukaryotic Cell
Vol/bind7
Udgave nummer9
Sider (fra-til)1611-5
Antal sider5
ISSN1535-9786
DOI
StatusUdgivet - sep. 2008

ID: 32952640