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Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus

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Oral administration of glucose stimulates insulin secretion to a greater extent than does glucose administered as an isoglycaemic intravenous glucose infusion. This phenomenon is called the incretin effect and is caused by the two incretin hormones GIP and GLP-1. In patients with type 2 diabetes, the incretin effect is impaired. The mechanisms of the impaired incretin effect have been found to involve reduced secretion of GLP-1 and a severely impaired effect of GIP. It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors.
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind169
Udgave nummer22
Sider (fra-til)2101-5
Antal sider5
ISSN0041-5782
StatusUdgivet - 28 maj 2007

ID: 34145135