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Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus

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The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11% of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.
OriginalsprogUdefineret/Ukendt
TidsskriftFood and Chemical Toxicology
Vol/bind38
Udgave nummer9
Sider (fra-til)739-746
Antal sider8
ISSN0278-6915
StatusUdgivet - 2000

    Forskningsområder

  • tangeretin rat citrus flavone metabolism HPLC liver epithelial-cells intercellular communication inhibition microsomes quercetin apigenin antioxidants biomarkers excretion enzymes

ID: 38061998