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Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort

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Body mass index and risk of autoimmune diseases : a study within the Danish National Birth Cohort. / Harpsøe, Maria C; Basit, Saima; Andersson, Mikael; Nielsen, Nete M; Frisch, Morten; Wohlfahrt, Jan; Nohr, Ellen A; Linneberg, Allan; Jess, Tine.

I: International Journal of Epidemiology, Bind 43, Nr. 3, 06.2014, s. 843-855.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Harpsøe, MC, Basit, S, Andersson, M, Nielsen, NM, Frisch, M, Wohlfahrt, J, Nohr, EA, Linneberg, A & Jess, T 2014, 'Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort', International Journal of Epidemiology, bind 43, nr. 3, s. 843-855. https://doi.org/10.1093/ije/dyu045

APA

Harpsøe, M. C., Basit, S., Andersson, M., Nielsen, N. M., Frisch, M., Wohlfahrt, J., ... Jess, T. (2014). Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort. International Journal of Epidemiology, 43(3), 843-855. https://doi.org/10.1093/ije/dyu045

Vancouver

Harpsøe MC, Basit S, Andersson M, Nielsen NM, Frisch M, Wohlfahrt J o.a. Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort. International Journal of Epidemiology. 2014 jun;43(3):843-855. https://doi.org/10.1093/ije/dyu045

Author

Harpsøe, Maria C ; Basit, Saima ; Andersson, Mikael ; Nielsen, Nete M ; Frisch, Morten ; Wohlfahrt, Jan ; Nohr, Ellen A ; Linneberg, Allan ; Jess, Tine. / Body mass index and risk of autoimmune diseases : a study within the Danish National Birth Cohort. I: International Journal of Epidemiology. 2014 ; Bind 43, Nr. 3. s. 843-855.

Bibtex

@article{4667f473f2244f8d9c944504cf92dd1a,
title = "Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort",
abstract = "BACKGROUND: A possible aetiological link between obesity and certain autoimmune diseases (ADs) has been suggested. We investigated the associations between body mass index (BMI, kg/m2) and 43 ADs.METHODS: 75,008 women participating in the Danish National Birth Cohort were followed during a median time of 11 years. Diagnoses on ADs were retrieved from the Danish National Patient Register. Cox proportional hazard ratios (HRs) with 95{\%} confidence intervals (CIs) were calculated adjusting for potential confounders (smoking, alcohol, parity and socio-occupational status).RESULTS: During follow-up, 2430 women (3.2{\%}) developed a total of 2607 new-onset ADs. Risk of any autoimmune disease was increased in obese women (HR, 1.27; 95{\%} CI, 1.11 to 1.46) compared with normal weight women (18.5-≤25 kg/m2). Obese women (BMI≥30 kg/m2) were at increased risk of sarcoidosis (HR 3.59; 95{\%} CI, 2.31 to 5.57) and type 1 diabetes mellitus (HR 2.67; 95{\%} CI, 1.71 to 4.17). Risk of dermatitis herpetiformis increased by 14{\%} (95{\%} CI, 1{\%} to 30{\%}) per BMI unit. Conversely, risk of celiac disease and Raynaud's phenomenon decreased by 7{\%} (95{\%} CI, 1{\%} to 13{\%}) and 12{\%} (95{\%} CI, 4{\%} to 19{\%}) per BMI unit, respectively. Further associations between BMI and risk of psoriasis, rheumatoid arthritis and Crohn's disease were suggested.CONCLUSIONS: BMI was found to be associated with several Ads. This was most pronounced between obesity and risk of sarcoidosis and and risk of type 1 diabetes mellitus. These novel findings need confirmation and the possible role of adipose tissue-derived immunological changes in the development of autoimmune reactions needs consideration.",
keywords = "Adult, Autoimmune Diseases, Body Mass Index, Cohort Studies, Denmark, Female, Health Behavior, Humans, Incidence, Longitudinal Studies, Obesity, Risk Factors, Socioeconomic Factors",
author = "Harps{\o}e, {Maria C} and Saima Basit and Mikael Andersson and Nielsen, {Nete M} and Morten Frisch and Jan Wohlfahrt and Nohr, {Ellen A} and Allan Linneberg and Tine Jess",
note = "{\circledC} The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.",
year = "2014",
month = "6",
doi = "10.1093/ije/dyu045",
language = "English",
volume = "43",
pages = "843--855",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Body mass index and risk of autoimmune diseases

T2 - a study within the Danish National Birth Cohort

AU - Harpsøe, Maria C

AU - Basit, Saima

AU - Andersson, Mikael

AU - Nielsen, Nete M

AU - Frisch, Morten

AU - Wohlfahrt, Jan

AU - Nohr, Ellen A

AU - Linneberg, Allan

AU - Jess, Tine

N1 - © The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2014/6

Y1 - 2014/6

N2 - BACKGROUND: A possible aetiological link between obesity and certain autoimmune diseases (ADs) has been suggested. We investigated the associations between body mass index (BMI, kg/m2) and 43 ADs.METHODS: 75,008 women participating in the Danish National Birth Cohort were followed during a median time of 11 years. Diagnoses on ADs were retrieved from the Danish National Patient Register. Cox proportional hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated adjusting for potential confounders (smoking, alcohol, parity and socio-occupational status).RESULTS: During follow-up, 2430 women (3.2%) developed a total of 2607 new-onset ADs. Risk of any autoimmune disease was increased in obese women (HR, 1.27; 95% CI, 1.11 to 1.46) compared with normal weight women (18.5-≤25 kg/m2). Obese women (BMI≥30 kg/m2) were at increased risk of sarcoidosis (HR 3.59; 95% CI, 2.31 to 5.57) and type 1 diabetes mellitus (HR 2.67; 95% CI, 1.71 to 4.17). Risk of dermatitis herpetiformis increased by 14% (95% CI, 1% to 30%) per BMI unit. Conversely, risk of celiac disease and Raynaud's phenomenon decreased by 7% (95% CI, 1% to 13%) and 12% (95% CI, 4% to 19%) per BMI unit, respectively. Further associations between BMI and risk of psoriasis, rheumatoid arthritis and Crohn's disease were suggested.CONCLUSIONS: BMI was found to be associated with several Ads. This was most pronounced between obesity and risk of sarcoidosis and and risk of type 1 diabetes mellitus. These novel findings need confirmation and the possible role of adipose tissue-derived immunological changes in the development of autoimmune reactions needs consideration.

AB - BACKGROUND: A possible aetiological link between obesity and certain autoimmune diseases (ADs) has been suggested. We investigated the associations between body mass index (BMI, kg/m2) and 43 ADs.METHODS: 75,008 women participating in the Danish National Birth Cohort were followed during a median time of 11 years. Diagnoses on ADs were retrieved from the Danish National Patient Register. Cox proportional hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated adjusting for potential confounders (smoking, alcohol, parity and socio-occupational status).RESULTS: During follow-up, 2430 women (3.2%) developed a total of 2607 new-onset ADs. Risk of any autoimmune disease was increased in obese women (HR, 1.27; 95% CI, 1.11 to 1.46) compared with normal weight women (18.5-≤25 kg/m2). Obese women (BMI≥30 kg/m2) were at increased risk of sarcoidosis (HR 3.59; 95% CI, 2.31 to 5.57) and type 1 diabetes mellitus (HR 2.67; 95% CI, 1.71 to 4.17). Risk of dermatitis herpetiformis increased by 14% (95% CI, 1% to 30%) per BMI unit. Conversely, risk of celiac disease and Raynaud's phenomenon decreased by 7% (95% CI, 1% to 13%) and 12% (95% CI, 4% to 19%) per BMI unit, respectively. Further associations between BMI and risk of psoriasis, rheumatoid arthritis and Crohn's disease were suggested.CONCLUSIONS: BMI was found to be associated with several Ads. This was most pronounced between obesity and risk of sarcoidosis and and risk of type 1 diabetes mellitus. These novel findings need confirmation and the possible role of adipose tissue-derived immunological changes in the development of autoimmune reactions needs consideration.

KW - Adult

KW - Autoimmune Diseases

KW - Body Mass Index

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Health Behavior

KW - Humans

KW - Incidence

KW - Longitudinal Studies

KW - Obesity

KW - Risk Factors

KW - Socioeconomic Factors

U2 - 10.1093/ije/dyu045

DO - 10.1093/ije/dyu045

M3 - Journal article

C2 - 24609069

VL - 43

SP - 843

EP - 855

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 3

ER -

ID: 137506133