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Borrelia infection and risk of non-Hodgkin lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • C. Schollkopf
  • M. Melbye
  • L. Munksgaard
  • K.E. Smedby
  • K. Rostgaard
  • B. Glimelius
  • E.T. Chang
  • G. Roos
  • M. Hansen
  • H.O. Adami
  • H. Hjalgrim
Reports of the presence of Borrelia burgdorferi DNA in malignant lymphomas have raised the hypothesis that infection with B. burgdorferi may be causally related to non-Hodgkin lymphoma (NHL) development. We conducted a Danish-Swedish case-control study including 3055 NHL patients and 3187 population controls. History of tick bite or Borrelia infection was ascertained through structured telephone interviews and through enzyme-linked immunosorbent assay serum analyses for antibodies against B. burgdorferi in a subset of 1579 patients and 1358 controls. Statistical associations with risk of NHL, including histologic subtypes, were assessed by logistic regression. Overall risk of NHL was not associated with self-reported history of tick bite (odds ratio [OR] = 1.0; 95% confidence interval: 0.9-1.1), Borrelia infection (OR = 1.3 [0.96-1.8]) or the presence of anti-Borrelia antibodies (OR = 1.3 [0.9-2.0]). However, in analyses of NHL subtypes, self-reported history of B. burgdorferi infection (OR = 2.5 [1.2-5.1]) and seropositivity for anti-Borrelia antibodies (OR = 3.6 [1.8-7.4]) were both associated with risk of mantle cell lymphoma. Notably, this specific association was also observed in persons who did not recall Borrelia infection yet tested positive for anti-Borrelia antibodies (OR = 4.2 [2.0-8.9]). Our observations suggest a previously unreported association between B. burgdorferi infection and risk of mantle cell lymphoma
Udgivelsesdato: 2008/6/15
OriginalsprogEngelsk
TidsskriftBlood
Vol/bind111
Udgave nummer12
Sider (fra-til)5524-5529
Antal sider5
ISSN0006-4971
StatusUdgivet - 2008

ID: 14276363