Forskning ved Københavns Universitet - Københavns Universitet

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Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans

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Administration of erythropoietin (EPO) has been linked to cerebrovascular events. EPO reduces vascular conductance, possibly because of the increase in hematocrit. Whether EPO in itself affects the vasculature remains unknown; here it was evaluated in healthy males by determining systemic and cerebrovascular variables following acute (30,000 IU/d for 3 d; n=8) and chronic (5000 IU/week for 13 wk; n=8) administration of EPO, while the responsiveness of the vasculature was challenged during cycling exercise, with and without hypoxia. Prolonged administration of EPO increased hematocrit from 42.5 ± 3.7 to 47.6 ± 4.1% (P
OriginalsprogEngelsk
TidsskriftFASEB journal : official publication of the Federation of American Societies for Experimental Biology
Vol/bind26
Udgave nummer3
Sider (fra-til)1343-8
Antal sider6
ISSN0892-6638
DOI
StatusUdgivet - mar. 2012

ID: 47239568