Forskning ved Københavns Universitet - Københavns Universitet


Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Administration of erythropoietin (EPO) has been linked to cerebrovascular events. EPO reduces vascular conductance, possibly because of the increase in hematocrit. Whether EPO in itself affects the vasculature remains unknown; here it was evaluated in healthy males by determining systemic and cerebrovascular variables following acute (30,000 IU/d for 3 d; n=8) and chronic (5000 IU/week for 13 wk; n=8) administration of EPO, while the responsiveness of the vasculature was challenged during cycling exercise, with and without hypoxia. Prolonged administration of EPO increased hematocrit from 42.5 ± 3.7 to 47.6 ± 4.1% (P
TidsskriftFASEB journal : official publication of the Federation of American Societies for Experimental Biology
Udgave nummer3
Sider (fra-til)1343-8
Antal sider6
StatusUdgivet - mar. 2012

ID: 47239568