Forskning ved Københavns Universitet - Københavns Universitet

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Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

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Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P
OriginalsprogEngelsk
TidsskriftF A S E B Journal
Vol/bind26
Udgave nummer5
Sider (fra-til)1831-1834
Antal sider4
ISSN0892-6638
DOI
StatusUdgivet - 2012

Bibliografisk note

CURIS 2012 5200 024

ID: 37588374