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Brain energetics during the sleep-wake cycle

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

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  • nihms908215

    Accepteret manuskript, 693 KB, PDF-dokument

Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid. These events are accompanied by changes in neuronal discharge patterns, astrocyte-neuron interactions, synaptic transactions and underlying metabolic features. Internally-generated neuronal activity and network homeostasis are proposed to account for the high sleep-related energy demand.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Neurobiology
Vol/bind47
Sider (fra-til)65-72
Antal sider8
ISSN0959-4388
DOI
StatusUdgivet - dec. 2017

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