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Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death

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The ability of cytotoxic T lymphocytes (CTL) to control and influence the outcome of human immunodeficiency virus (HIV) infection is not fully understood. The association between HIV-CTL activity and disease progression was evaluated prospectively in 36 HIV-1-infected individuals with a median follow-up of 3.0 years. HIV-CTL activity was measured in a 4 h Cr* release assay using autologous target cells expressing HIV-1 BRU isolate gene products (gp-120, gag, pol, nef) and a bulk culture of autologous effector cells. The CD4 count was measured at enrolment and plasma HIV RNA was measured retrospectively. The present study failed to support the hypothesis that HIV-CTL activity, as measured using the present method, is important in reducing the risk of death in HIV-infected individuals. However, using other approaches and methods could possibly yield other conclusions, and further prospective studies are needed to examine the relationship between CTL and disease progression.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Immunology
Vol/bind50
Udgave nummer2
Sider (fra-til)223-7
Antal sider5
ISSN0300-9475
StatusUdgivet - aug. 1999

ID: 180572145