Forskning ved Københavns Universitet - Københavns Universitet


Calcium in Cell-Extracellular Matrix Interactions

Publikation: Bidrag til tidsskriftReview

In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

BogserieAdvances in Experimental Medicine and Biology
Sider (fra-til)1079-1102
Antal sider24
StatusUdgivet - 2020

ID: 231600595