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Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A number of different statistics are used for detecting natural selection using DNA sequencing data, including statistics that are summaries of the frequency spectrum, such as Tajima's D. These statistics are now often being applied in the analysis of Next Generation Sequencing (NGS) data. However, estimates of frequency spectra from NGS data are strongly affected by low sequencing coverage; the inherent technology dependent variation in sequencing depth causes systematic differences in the value of the statistic among genomic regions.
OriginalsprogEngelsk
Artikelnummer289
TidsskriftB M C Bioinformatics
Vol/bind14
Antal sider14
ISSN1471-2105
DOI
StatusUdgivet - 2013

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