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Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure

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Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure. / St John Sutton, Martin; Ghio, Stefano; Plappert, Ted; Tavazzi, Luigi; Scelsi, Laura; Daubert, Claude; Abraham, William T; Gold, Michael R; Hassager, Christian; Herre, John M; Linde, Cecilia; REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group.

I: Circulation, Bind 120, Nr. 19, 2009, s. 1858-65.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

St John Sutton, M, Ghio, S, Plappert, T, Tavazzi, L, Scelsi, L, Daubert, C, Abraham, WT, Gold, MR, Hassager, C, Herre, JM, Linde, C & REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group 2009, 'Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure', Circulation, bind 120, nr. 19, s. 1858-65. https://doi.org/10.1161/CIRCULATIONAHA.108.818724

APA

St John Sutton, M., Ghio, S., Plappert, T., Tavazzi, L., Scelsi, L., Daubert, C., Abraham, W. T., Gold, M. R., Hassager, C., Herre, J. M., Linde, C., & REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group (2009). Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure. Circulation, 120(19), 1858-65. https://doi.org/10.1161/CIRCULATIONAHA.108.818724

Vancouver

St John Sutton M, Ghio S, Plappert T, Tavazzi L, Scelsi L, Daubert C o.a. Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure. Circulation. 2009;120(19):1858-65. https://doi.org/10.1161/CIRCULATIONAHA.108.818724

Author

St John Sutton, Martin ; Ghio, Stefano ; Plappert, Ted ; Tavazzi, Luigi ; Scelsi, Laura ; Daubert, Claude ; Abraham, William T ; Gold, Michael R ; Hassager, Christian ; Herre, John M ; Linde, Cecilia ; REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group. / Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure. I: Circulation. 2009 ; Bind 120, Nr. 19. s. 1858-65.

Bibtex

@article{9265aa1067d711df928f000ea68e967b,
title = "Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure",
abstract = "BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure. METHODS AND RESULTS: Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration > or =120 ms, LV end-diastolic dimension > or =55 mm, and LV ejection fraction < or =40% were randomized to active therapy (CRT on; n=419) or control (CRT off; n=191) for 12 months. Doppler echocardiograms were recorded at baseline, before hospital discharge, and at 6 and 12 months. When CRT was turned on initially, immediate changes occurred in LV volumes and ejection fraction; however, these changes did not correlate with the long-term changes (12 months) in LV end-systolic (r=0.11, P=0.31) or end-diastolic (r=0.10, P=0.38) volume indexes or LV ejection fraction (r=0.07, P=0.72). LV end-diastolic and end-systolic volume indexes decreased in patients with CRT turned on (both P<0.001 compared with CRT off), whereas LV ejection fraction in CRT-on patients increased (P<0.0001 compared with CRT off) from baseline through 12 months. LV mass, mitral regurgitation, and LV diastolic function did not change in either group by 12 months; however, there was a 3-fold greater reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure. CONCLUSIONS: CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes occurring in patients with a nonischemic cause of heart failure. CRT may interrupt the natural disease progression in these patients. Clinical Trial Registration- Clinicaltrials.gov Identifier: NCT00271154.",
author = "{St John Sutton}, Martin and Stefano Ghio and Ted Plappert and Luigi Tavazzi and Laura Scelsi and Claude Daubert and Abraham, {William T} and Gold, {Michael R} and Christian Hassager and Herre, {John M} and Cecilia Linde and {REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group}",
note = "Keywords: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiac Pacing, Artificial; Cardiac Volume; Combined Modality Therapy; Echocardiography, Doppler; Electrocardiography; Female; Heart Failure, Systolic; Humans; Male; Middle Aged; Severity of Illness Index; Stroke Volume; Treatment Outcome; Ventricular Remodeling",
year = "2009",
doi = "10.1161/CIRCULATIONAHA.108.818724",
language = "English",
volume = "120",
pages = "1858--65",
journal = "Circulation",
issn = "0009-7322",
publisher = "AHA/ASA",
number = "19",

}

RIS

TY - JOUR

T1 - Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure

AU - St John Sutton, Martin

AU - Ghio, Stefano

AU - Plappert, Ted

AU - Tavazzi, Luigi

AU - Scelsi, Laura

AU - Daubert, Claude

AU - Abraham, William T

AU - Gold, Michael R

AU - Hassager, Christian

AU - Herre, John M

AU - Linde, Cecilia

AU - REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) Study Group

N1 - Keywords: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiac Pacing, Artificial; Cardiac Volume; Combined Modality Therapy; Echocardiography, Doppler; Electrocardiography; Female; Heart Failure, Systolic; Humans; Male; Middle Aged; Severity of Illness Index; Stroke Volume; Treatment Outcome; Ventricular Remodeling

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure. METHODS AND RESULTS: Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration > or =120 ms, LV end-diastolic dimension > or =55 mm, and LV ejection fraction < or =40% were randomized to active therapy (CRT on; n=419) or control (CRT off; n=191) for 12 months. Doppler echocardiograms were recorded at baseline, before hospital discharge, and at 6 and 12 months. When CRT was turned on initially, immediate changes occurred in LV volumes and ejection fraction; however, these changes did not correlate with the long-term changes (12 months) in LV end-systolic (r=0.11, P=0.31) or end-diastolic (r=0.10, P=0.38) volume indexes or LV ejection fraction (r=0.07, P=0.72). LV end-diastolic and end-systolic volume indexes decreased in patients with CRT turned on (both P<0.001 compared with CRT off), whereas LV ejection fraction in CRT-on patients increased (P<0.0001 compared with CRT off) from baseline through 12 months. LV mass, mitral regurgitation, and LV diastolic function did not change in either group by 12 months; however, there was a 3-fold greater reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure. CONCLUSIONS: CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes occurring in patients with a nonischemic cause of heart failure. CRT may interrupt the natural disease progression in these patients. Clinical Trial Registration- Clinicaltrials.gov Identifier: NCT00271154.

AB - BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure. METHODS AND RESULTS: Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration > or =120 ms, LV end-diastolic dimension > or =55 mm, and LV ejection fraction < or =40% were randomized to active therapy (CRT on; n=419) or control (CRT off; n=191) for 12 months. Doppler echocardiograms were recorded at baseline, before hospital discharge, and at 6 and 12 months. When CRT was turned on initially, immediate changes occurred in LV volumes and ejection fraction; however, these changes did not correlate with the long-term changes (12 months) in LV end-systolic (r=0.11, P=0.31) or end-diastolic (r=0.10, P=0.38) volume indexes or LV ejection fraction (r=0.07, P=0.72). LV end-diastolic and end-systolic volume indexes decreased in patients with CRT turned on (both P<0.001 compared with CRT off), whereas LV ejection fraction in CRT-on patients increased (P<0.0001 compared with CRT off) from baseline through 12 months. LV mass, mitral regurgitation, and LV diastolic function did not change in either group by 12 months; however, there was a 3-fold greater reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure. CONCLUSIONS: CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes occurring in patients with a nonischemic cause of heart failure. CRT may interrupt the natural disease progression in these patients. Clinical Trial Registration- Clinicaltrials.gov Identifier: NCT00271154.

U2 - 10.1161/CIRCULATIONAHA.108.818724

DO - 10.1161/CIRCULATIONAHA.108.818724

M3 - Journal article

C2 - 19858419

VL - 120

SP - 1858

EP - 1865

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 19

ER -

ID: 19951977