Forskning ved Københavns Universitet - Københavns Universitet


Casein improves brachial and central aortic diastolic blood pressure in overweight adolescents: A randomised, controlled trial

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Arterial stiffness, blood pressure (BP) and blood lipids may be improved by milk in adults and the effects may be mediated via proteins. However, limited is
known about the effects of milk proteins on central aortic BP and no studies have examined the effects in children. Therefore, the present trial examined the
effect of milk and milk proteins on brachial and central aortic BP, blood lipids, inflammation and arterial stiffness in overweight adolescents. A randomised
controlled trial was conducted in 193 overweight adolescents aged 12–15 years. They were randomly assigned to drink 1 litre of water, skimmed milk, whey
or casein for 12 weeks. The milk-based test drinks contained 35 g protein/l. The effects were compared with the water group and a pretest control group
consisting of thirty-two of the adolescents followed 12 weeks before the start of the intervention. Outcomes were brachial and central aortic BP, pulse wave
velocity and augmentation index, serum C-reactive protein and blood lipids. Brachial and central aortic diastolic BP (DBP) decreased by 2·7% (P = 0·036)
and 2·6%(P = 0·048), respectively, within the casein group and the changes were significantly different from those of the pretest control group (P = 0·040
and P = 0·034, respectively). There was a significant increase in central aortic DBP, and in brachial and central systolic BP in the whey group compared with
the water group (P = 0·003, P = 0·009 and P = 0·002, respectively). There were no changes in measures of arterial stiffness or blood lipid concentrations. A
high intake of casein improves DBP in overweight adolescents. Thus, casein may be beneficial for younger overweight subjects in terms of reducing the longterm
risk of CVD. In contrast, whey protein seems to increase BP compared with drinking water; however, water may be considered an active control group.
TidsskriftJournal of Nutritional Science
Antal sider10
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 360

ID: 140197285