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Cavity-enhanced optical frequency combspectroscopy: Application to human breathanalysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • David Morten Balslev-Clausen
  • M. J. Thorpe
  • M. S. Kirchner
  • J. Ye
Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10-10cm-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO2, breath concentrations of CO, and the presence of trace concentrations of NH3 in high concentrations of H2O.
Udgivelsesdato: 02.05
OriginalsprogEngelsk
TidsskriftOptics Express
Vol/bind16
Udgave nummer4
Sider (fra-til)2387-2397
Antal sider10
ISSN1094-4087
DOI
StatusUdgivet - 2008

ID: 10732362