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Cerebral glucose metabolism in long-term survivors of childhood primary brain tumors treated with surgery and radiotherapy.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Preben B. Andersen
  • Katja Krabbe
  • Anne M. Leffers
  • Marianne Schmiegelow
  • Søren Holm
  • Henning Laursen
  • Jørn R. Müller
  • Paulson, Olaf B.
Delayed structural cerebral sequelae has been reported following cranial radiation therapy (CRT) to children with primary brain tumors, but little is known about potential functional changes. Twenty-four patients were included, diagnosed and treated at a median age of 11 years, and examined after a median recurrence free survival of 16 years by MRI and Positron Emission Tomography using the glucose analog 2-18F-fluoro-2-deoxy-D-glucose (18FDG). Three patients were not analyzed further due to diffuse cerebral atrophy, which might be related to previous hydrocephalus. Twenty-one patients were evaluable and regional cerebral metabolic rate for glucose (rCMRglc) was estimated in nontumoral brain regions in 12 patients treated with surgery alone and 9 patients treated with both surgery and CRT. Furthermore 10 normal controls matched for age at examination were included. Patients treated with both surgery and CRT had a general decreased rCMRglc compared to normal controls and patients treated with surgery alone, significantly (p < 0.05) in 5 of 11 regions of interest. No difference was found in rCMRglc between normal controls and patients treated with surgery alone. We conclude that there is a general reduction in rCMRglc in long-term recurrence free survivors of childhood primary brain tumors treated with CRT in high doses (44-56 Gy)
OriginalsprogEngelsk
TidsskriftJ Neurooncol
Vol/bind62
Udgave nummer3
Sider (fra-til)305-313
StatusUdgivet - 2003

ID: 34059321