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Cerebral vasoconstriction after subarachnoid hemorrhage--role of changes in vascular receptor phenotype

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The pathological constriction of cerebral arteries known as cerebral vasospasm (CVS) is with a delay of 4 to 10 days linked to subarachnoid hemorrhage. Several agents have been suggested as being responsible; amongst these perhaps 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1) are the most prominent given their ability to elicit powerful constriction of cerebral arteries. Investigating both 5-HT and ET receptors we have observed that there are distinct changes in receptor phenotype after experimental SAH, namely upregulation of the ETB and 5-HT1B receptors, and that this upregulation is linked to a higher sensitivity to the endogenous agonists. It has also been shown that reduction in regional cerebral blood flow (CBF) is associated with receptor upregulation and interventional animal experiments have shown a benefit from inhibiting the PKC and MAP kinase pathways on receptor upregulation, CBF and neurological outcome
Udgivelsesdato: 2008
OriginalsprogEngelsk
TidsskriftFrontiers in Bioscience
Vol/bind13
Sider (fra-til)2160-2164
Antal sider4
ISSN1093-9946
StatusUdgivet - 2008

Bibliografisk note

IS - 1093-4715 (Electronic)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tPT - ReviewRN - 0 (Receptors, Serotonin)SB - IM

ID: 10912890