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Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

  • C. Frederiksen
  • A.F. Lomholt
  • G.J. Davis
  • B.L. Dowell
  • M.A. Blankenstein
  • I.J. Christensen
  • Brünner, Nils
  • H.J. Nielsen
BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT Immunoanalyzer. RESULTS: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p < 0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. CONCLUSION: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively.
OriginalsprogEngelsk
TidsskriftAnticancer Research
Vol/bind29
Udgave nummer1
Sider (fra-til)75-82
Antal sider8
ISSN0250-7005
StatusUdgivet - 2009

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