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Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

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Background: Our knowledge about longtudinal predictors of atopy is limited. Objectives: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes. Methods: From a sample of 1, 186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart. Results: In total, 134 (39% of the Study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 min for a positive test result 77 (22%) developed de novo sensitizations to I or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57] P =.04) significantly predicted incidence of 1 or more sensitizations. Conclusions: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men
Udgivelsesdato: 2008/11
OriginalsprogEngelsk
TidsskriftAnnals of Allergy, Asthma, & Immunology
Vol/bind101
Udgave nummer5
Sider (fra-til)524-528
Antal sider4
ISSN1081-1206
StatusUdgivet - 2008

Bibliografisk note

Times Cited: 0ArticleEnglishThomsen, S. FBispebjerg Hosp, Dept Resp Med, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, DenmarkCited References Count: 25369WYAMER COLL ALLERGY ASTHMA IMMUNOLOGY85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USAARLINGTON HTS

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