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Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice : a retrospective registry based cohort study. / Aabenhus, Rune; Hansen, Malene Plejdrup; Saust, Laura Trolle; Bjerrum, Lars.

I: npj Primary Care Respiratory Medicine, Bind 27, 37, 19.05.2017, s. 1-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Aabenhus, R, Hansen, MP, Saust, LT & Bjerrum, L 2017, 'Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study', npj Primary Care Respiratory Medicine, bind 27, 37, s. 1-6. https://doi.org/10.1038/s41533-017-0037-7

APA

Aabenhus, R., Hansen, M. P., Saust, L. T., & Bjerrum, L. (2017). Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study. npj Primary Care Respiratory Medicine, 27, 1-6. [37]. https://doi.org/10.1038/s41533-017-0037-7

Vancouver

Aabenhus R, Hansen MP, Saust LT, Bjerrum L. Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study. npj Primary Care Respiratory Medicine. 2017 maj 19;27:1-6. 37. https://doi.org/10.1038/s41533-017-0037-7

Author

Aabenhus, Rune ; Hansen, Malene Plejdrup ; Saust, Laura Trolle ; Bjerrum, Lars. / Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice : a retrospective registry based cohort study. I: npj Primary Care Respiratory Medicine. 2017 ; Bind 27. s. 1-6.

Bibtex

@article{b0783af6077d4162b2bf00f30875d7b9,
title = "Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study",
abstract = "Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendations are followed. We aimed to characterise the pattern of antibiotic prescriptions for patients diagnosed with acute respiratory tract infections, by means of electronic prescriptions, labeled with clinical indications, from Danish general practice. Acute respiratory tract infections accounted for 456,532 antibiotic prescriptions issued between July 2012 and June 2013. Pneumonia was the most common indication with 178,354 prescriptions (39{\%}), followed by acute tonsillitis (21{\%}) and acute otitis media (19{\%}). In total, penicillin V accounted for 58{\%} of all prescriptions, followed by macrolides (18{\%}) and amoxicillin (15{\%}). The use of second-line agents increased with age for all indications, and comprised more than 40{\%} of the prescriptions in patients aged >75 years. Women were more often prescribed antibiotics regardless of clinical indication. This is the first Danish study to characterise antibiotic prescription patterns for acute respiratory tract infections by data linkage of clinical indications. The findings confirm that penicillin V is the most commonly prescribed antibiotic agent for treatment of patients with an acute respiratory tract infection in Danish general practice. However, second-line agents like macrolides and amoxicillin with or without clavulanic acid are overused. Strategies to improve the quality of antibiotic prescribing especially for pneumonia, acute otitis media and acute rhinosinusitis are warranted.",
author = "Rune Aabenhus and Hansen, {Malene Plejdrup} and Saust, {Laura Trolle} and Lars Bjerrum",
year = "2017",
month = "5",
day = "19",
doi = "10.1038/s41533-017-0037-7",
language = "English",
volume = "27",
pages = "1--6",
journal = "n p j Primary Care Respiratory Medicine",
issn = "2055-1010",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice

T2 - a retrospective registry based cohort study

AU - Aabenhus, Rune

AU - Hansen, Malene Plejdrup

AU - Saust, Laura Trolle

AU - Bjerrum, Lars

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendations are followed. We aimed to characterise the pattern of antibiotic prescriptions for patients diagnosed with acute respiratory tract infections, by means of electronic prescriptions, labeled with clinical indications, from Danish general practice. Acute respiratory tract infections accounted for 456,532 antibiotic prescriptions issued between July 2012 and June 2013. Pneumonia was the most common indication with 178,354 prescriptions (39%), followed by acute tonsillitis (21%) and acute otitis media (19%). In total, penicillin V accounted for 58% of all prescriptions, followed by macrolides (18%) and amoxicillin (15%). The use of second-line agents increased with age for all indications, and comprised more than 40% of the prescriptions in patients aged >75 years. Women were more often prescribed antibiotics regardless of clinical indication. This is the first Danish study to characterise antibiotic prescription patterns for acute respiratory tract infections by data linkage of clinical indications. The findings confirm that penicillin V is the most commonly prescribed antibiotic agent for treatment of patients with an acute respiratory tract infection in Danish general practice. However, second-line agents like macrolides and amoxicillin with or without clavulanic acid are overused. Strategies to improve the quality of antibiotic prescribing especially for pneumonia, acute otitis media and acute rhinosinusitis are warranted.

AB - Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendations are followed. We aimed to characterise the pattern of antibiotic prescriptions for patients diagnosed with acute respiratory tract infections, by means of electronic prescriptions, labeled with clinical indications, from Danish general practice. Acute respiratory tract infections accounted for 456,532 antibiotic prescriptions issued between July 2012 and June 2013. Pneumonia was the most common indication with 178,354 prescriptions (39%), followed by acute tonsillitis (21%) and acute otitis media (19%). In total, penicillin V accounted for 58% of all prescriptions, followed by macrolides (18%) and amoxicillin (15%). The use of second-line agents increased with age for all indications, and comprised more than 40% of the prescriptions in patients aged >75 years. Women were more often prescribed antibiotics regardless of clinical indication. This is the first Danish study to characterise antibiotic prescription patterns for acute respiratory tract infections by data linkage of clinical indications. The findings confirm that penicillin V is the most commonly prescribed antibiotic agent for treatment of patients with an acute respiratory tract infection in Danish general practice. However, second-line agents like macrolides and amoxicillin with or without clavulanic acid are overused. Strategies to improve the quality of antibiotic prescribing especially for pneumonia, acute otitis media and acute rhinosinusitis are warranted.

U2 - 10.1038/s41533-017-0037-7

DO - 10.1038/s41533-017-0037-7

M3 - Journal article

C2 - 28526836

VL - 27

SP - 1

EP - 6

JO - n p j Primary Care Respiratory Medicine

JF - n p j Primary Care Respiratory Medicine

SN - 2055-1010

M1 - 37

ER -

ID: 186997049