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Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test

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Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.
OriginalsprogEngelsk
TidsskriftPsychopharmacology
Vol/bind205
Udgave nummer3
Sider (fra-til)517-28
Antal sider12
ISSN0033-3158
DOI
StatusUdgivet - 1 aug. 2009

ID: 34329132