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Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer

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Standard

Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. / Werther, Kim; Sørensen, Steen; Christensen, Ib Jarle; Nielsen, Hans Jørgen.

I: Acta Oncologica, Bind 42, Nr. 8, 2003, s. 837-845.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Werther, K, Sørensen, S, Christensen, IJ & Nielsen, HJ 2003, 'Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer', Acta Oncologica, bind 42, nr. 8, s. 837-845.

APA

Werther, K., Sørensen, S., Christensen, I. J., & Nielsen, H. J. (2003). Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. Acta Oncologica, 42(8), 837-845.

Vancouver

Werther K, Sørensen S, Christensen IJ, Nielsen HJ. Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. Acta Oncologica. 2003;42(8):837-845.

Author

Werther, Kim ; Sørensen, Steen ; Christensen, Ib Jarle ; Nielsen, Hans Jørgen. / Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. I: Acta Oncologica. 2003 ; Bind 42, Nr. 8. s. 837-845.

Bibtex

@article{98070a634ed545fca0543d2d32b3fa51,
title = "Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer",
abstract = "High preoperative circulating vascular endothelial growth factor (VEGF) is predictive of poor prognosis in patients with colorectal cancer (CRC). However, postoperative circulating VEGF has not yet been evaluated as a prognostic marker in CRC patients. In 318 consecutive patients who had undergone curative resection of primary CRC, the prognostic value of VEGF concentrations in plasma and serum obtained 6 months postoperatively was analysed and the results compared with the prognostic value of postoperative carcinoembryonic antigen (CEA) concentrations in matched serum samples. In univariate analyses, high serum and plasma VEGF ( > 533 pg/ml and > 112 pg/ml, respectively) had no significant (p = 0.17 and p = 0.13, respectively) impact on overall survival. On the contrary, high serum CEA ( > 5 ng/ ml) was significantly (p < 0.0001) correlated to a poor prognosis. Finally, in multivariate analyses, the combination of high serum CEA and high serum VEGF was significantly (hazard ratio 3.0, p = 0.02) associated with poor survival compared to high serum CEA and low serum VEGF. It is concluded that 6 months postoperatively serum CEA is a better prognostic marker than corresponding serum and plasma VEGF. However, high serum VEGF within high serum CEA was an even better predictor of overall survival than high serum CEA alone.",
author = "Kim Werther and Steen S{\o}rensen and Christensen, {Ib Jarle} and Nielsen, {Hans J{\o}rgen}",
year = "2003",
language = "English",
volume = "42",
pages = "837--845",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Taylor & Francis",
number = "8",

}

RIS

TY - JOUR

T1 - Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer

AU - Werther, Kim

AU - Sørensen, Steen

AU - Christensen, Ib Jarle

AU - Nielsen, Hans Jørgen

PY - 2003

Y1 - 2003

N2 - High preoperative circulating vascular endothelial growth factor (VEGF) is predictive of poor prognosis in patients with colorectal cancer (CRC). However, postoperative circulating VEGF has not yet been evaluated as a prognostic marker in CRC patients. In 318 consecutive patients who had undergone curative resection of primary CRC, the prognostic value of VEGF concentrations in plasma and serum obtained 6 months postoperatively was analysed and the results compared with the prognostic value of postoperative carcinoembryonic antigen (CEA) concentrations in matched serum samples. In univariate analyses, high serum and plasma VEGF ( > 533 pg/ml and > 112 pg/ml, respectively) had no significant (p = 0.17 and p = 0.13, respectively) impact on overall survival. On the contrary, high serum CEA ( > 5 ng/ ml) was significantly (p < 0.0001) correlated to a poor prognosis. Finally, in multivariate analyses, the combination of high serum CEA and high serum VEGF was significantly (hazard ratio 3.0, p = 0.02) associated with poor survival compared to high serum CEA and low serum VEGF. It is concluded that 6 months postoperatively serum CEA is a better prognostic marker than corresponding serum and plasma VEGF. However, high serum VEGF within high serum CEA was an even better predictor of overall survival than high serum CEA alone.

AB - High preoperative circulating vascular endothelial growth factor (VEGF) is predictive of poor prognosis in patients with colorectal cancer (CRC). However, postoperative circulating VEGF has not yet been evaluated as a prognostic marker in CRC patients. In 318 consecutive patients who had undergone curative resection of primary CRC, the prognostic value of VEGF concentrations in plasma and serum obtained 6 months postoperatively was analysed and the results compared with the prognostic value of postoperative carcinoembryonic antigen (CEA) concentrations in matched serum samples. In univariate analyses, high serum and plasma VEGF ( > 533 pg/ml and > 112 pg/ml, respectively) had no significant (p = 0.17 and p = 0.13, respectively) impact on overall survival. On the contrary, high serum CEA ( > 5 ng/ ml) was significantly (p < 0.0001) correlated to a poor prognosis. Finally, in multivariate analyses, the combination of high serum CEA and high serum VEGF was significantly (hazard ratio 3.0, p = 0.02) associated with poor survival compared to high serum CEA and low serum VEGF. It is concluded that 6 months postoperatively serum CEA is a better prognostic marker than corresponding serum and plasma VEGF. However, high serum VEGF within high serum CEA was an even better predictor of overall survival than high serum CEA alone.

M3 - Journal article

VL - 42

SP - 837

EP - 845

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 8

ER -

ID: 34082041