Forskning ved Københavns Universitet - Københavns Universitet


Classical swine fever virus infection modulates serum levels of INF-alpha, IL-8 and TNF-alpha in 6-month-old pigs

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  • T. von Rosen
  • L. Lohse
  • J. Nielsen
  • A. Uttenthal
Several studies have highlighted the important role of cytokines in disease development of classical swine fever virus (CSFV) infection. In the present study, we examined the kinetics of 7 porcine cytokines in serum from pigs infected with 3 different CSFV strains. Based on the clinical picture in 6-month-old Danish pigs, the strains used for inoculation were classified as being of low (Bergen), low to moderate (Eystrup) and moderate to high (Lithuania) virulence. The cytokines interferon-alpha (INF-alpha), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) showed increased levels after CSFV infection with more or less comparable course in the 3 groups. However, the cytokine level peaked with a 2-3 days delay in pigs infected with the low virulent strain compared to those infected with a moderately or highly virulent strain. These findings may indicate that INF-alpha, IL-8 and TNF-alpha are involved in the immune response during CSFV infection with strains of different virulence. (C) 2013 Elsevier Ltd. All rights reserved.
TidsskriftResearch in Veterinary Science
Udgave nummer3
Sider (fra-til)1262-1267
Antal sider6
StatusUdgivet - 2013

ID: 119412808