Forskning ved Københavns Universitet - Københavns Universitet


Clinical and epidemiological aspects of invasive Streptococcus pyogenes infections in Denmark during 2003 and 2004

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • B. Luca-Harari
  • M. van der Linden
  • M. Staum-Kattoft
  • A.M. Hammerum
  • A. Jasir
  • Ekelund, Kim
Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during 2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majority of isolates, 253 (91%), were from blood, with the remaining 25 (9%) being from cerebrospinal fluid, joints, or other normally sterile sites. The mean case fatality rate (CFR) was 20%, with the rate being higher in patients more than 70 years of age (36.5%). For streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis the CFRs were 53% and 25%, respectively. Out of 16 T types recorded, three predominated: T28 (23%), T1 (22%), and the cluster T3/13/B3264 (14%). Among 21) different emm types, emm28 and emm1 accounted for 51% of strains, followed by emm3 (11%), emm89 (7%), and emm12 (5.5%). Low resistance rates were detected for macrolide-lincosamide-streptogramin B (MLSB) antibiotics (3%) and tetracycline (8%); two isolates exhibited coresistance to tetracycline and macrolides. Of nine pyrogenic exotoxin (superantigen) genes examined, speA and speC were identified in 58% and 40% of the strains, respectively; either of the genes was present in all strains causing STSS. Most strains harbored speG (99%). ssa was present in 14% of the isolates only. In Denmark, as in comparable countries, GAS invasive disease shows a sustained, high endemicity, with involvement of both established and emerging streptococcal emm and T types
Udgivelsesdato: 2008/1
TidsskriftJournal of Clinical Microbiology
Udgave nummer1
Sider (fra-til)79-86
Antal sider7
StatusUdgivet - 2008

Bibliografisk note

Times Cited: 3ArticleEnglishJasir, ALund Univ, Dept Med Microbiol, Inst Lab Med, Solvegatan 23, S-22362 Lund, SwedenCited References Count: 60251RSAMER SOC MICROBIOLOGY1752 N ST NW, WASHINGTON, DC 20036-2904 USAWASHINGTON

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