Forskning ved Københavns Universitet - Københavns Universitet

Forside

Cockayne syndrome group B cellular and biochemical functions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Cecilie Löe Licht
  • Tinna V. Stevnsner
  • Vilhelm A Bohr
The devastating genetic disorder Cockayne syndrome (CS) arises from mutations in the CSA and CSB genes. CS is characterized by progressive multisystem degeneration and is classified as a segmental premature-aging syndrome. The CS complementation group B (CSB) protein is at the interface of transcription and DNA repair and is involved in transcription-coupled and global genome-DNA repair, as well as in general transcription. Recent structure-function studies indicate a process-dependent variation in the molecular mechanism employed by CSB and provide a starting ground for a description of the mechanisms and their interplay.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Human Genetics
Vol/bind73
Udgave nummer6
Sider (fra-til)1217-39
Antal sider23
ISSN0002-9297
DOI
StatusUdgivet - 1 dec. 2003
Eksternt udgivetJa

ID: 34397462