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Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. / Hassager, C; Jensen, L T; Pødenphant, J; Riis, B J; Christiansen, C.

I: Metabolism, Bind 39, Nr. 11, 11.1990, s. 1167-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hassager, C, Jensen, LT, Pødenphant, J, Riis, BJ & Christiansen, C 1990, 'Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones', Metabolism, bind 39, nr. 11, s. 1167-9.

APA

Hassager, C., Jensen, L. T., Pødenphant, J., Riis, B. J., & Christiansen, C. (1990). Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. Metabolism, 39(11), 1167-9.

Vancouver

Hassager C, Jensen LT, Pødenphant J, Riis BJ, Christiansen C. Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. Metabolism. 1990 nov;39(11):1167-9.

Author

Hassager, C ; Jensen, L T ; Pødenphant, J ; Riis, B J ; Christiansen, C. / Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. I: Metabolism. 1990 ; Bind 39, Nr. 11. s. 1167-9.

Bibtex

@article{da3df3c938ea405bbf40bc6ac3001d0a,
title = "Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones",
abstract = "The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50{\%} increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.",
keywords = "Aged, Anabolic Agents, Collagen, Drug Combinations, Estradiol, Female, Humans, Menopause, Middle Aged, Nandrolone, Norethindrone, Peptide Fragments, Procollagen, Clinical Trial, Controlled Clinical Trial, Journal Article",
author = "C Hassager and Jensen, {L T} and J P{\o}denphant and Riis, {B J} and C Christiansen",
year = "1990",
month = "11",
language = "English",
volume = "39",
pages = "1167--9",
journal = "Metabolism",
issn = "0026-0495",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones

AU - Hassager, C

AU - Jensen, L T

AU - Pødenphant, J

AU - Riis, B J

AU - Christiansen, C

PY - 1990/11

Y1 - 1990/11

N2 - The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.

AB - The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.

KW - Aged

KW - Anabolic Agents

KW - Collagen

KW - Drug Combinations

KW - Estradiol

KW - Female

KW - Humans

KW - Menopause

KW - Middle Aged

KW - Nandrolone

KW - Norethindrone

KW - Peptide Fragments

KW - Procollagen

KW - Clinical Trial

KW - Controlled Clinical Trial

KW - Journal Article

M3 - Journal article

C2 - 2233278

VL - 39

SP - 1167

EP - 1169

JO - Metabolism

JF - Metabolism

SN - 0026-0495

IS - 11

ER -

ID: 168533768