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Combinatorial chemistry of piperidine based carbohydrate mimics

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Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases.

OriginalsprogEngelsk
TidsskriftTetrahedron Letters
Vol/bind38
Udgave nummer32
Sider (fra-til)5697-5700
Antal sider4
ISSN0040-4039
DOI
StatusUdgivet - 1 aug. 1997

ID: 131114868