Forskning ved Københavns Universitet - Københavns Universitet


Comparison of the effects of two drying methods on polymorphism of theophylline

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Sari Airaksinen
  • Milja Karjalainen
  • Eetu Räsänen
  • Rantanen, Jukka
  • Jouko Yliruusi

Processing-induced transformations in drug formulation may induce adverse biopharmaceutical changes in the finished product. During the drying phase of wet granulation, theophylline monohydrate transforms either the stable (form I), or a polymorphic, metastable (form I(*)) form of anhydrous theophylline. We investigated the effect of two drying methods (multichamber microscale fluid bed dryer MMFD) or variable temperature X-ray powder diffractometer (VT-XRPD) on the relative amounts of the different theophylline forms remaining in the dried granules. Granules were analyzed using XRPD and near-infrared spectroscopy. Form I(*) was the predominant form of theophylline after drying at 40-50 degrees C with both drying techniques. Although drying at temperatures over 50 degrees C produced mostly form I, more than 20% of form I(*) remained even at 90 degrees C when drying in MMFD. In these conditions, humidity had little influence on the amount of form I(*) in the granules. In contrast, drying in a VT-XRPD at 60 degrees C produced form I already during the first 15min. Using additional drying methods, including MMFD, during the preformulation stage can be more informative about the possible polymorphic transformations and their underlying mechanisms, such as triboelectrification or recrystallization, in drug ingredients during the manufacturing process.

TidsskriftInternational Journal of Pharmaceutics
Udgave nummer1-2
Sider (fra-til)129-41
Antal sider13
StatusUdgivet - 19 maj 2004


  • Chemistry, Pharmaceutical, Polymorphism, Genetic, Theophylline, Vasodilator Agents, X-Ray Diffraction

ID: 140622093