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Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis

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Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis. / Vainer, Ben; Nielsen, O. Haagen.

I: Scandinavian Journal of Gastroenterology, Bind 38, Nr. 3, 01.03.2003, s. 283-287.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Vainer, B & Nielsen, OH 2003, 'Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis', Scandinavian Journal of Gastroenterology, bind 38, nr. 3, s. 283-287. https://doi.org/10.1080/00365520310000609a

APA

Vainer, B., & Nielsen, O. H. (2003). Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis. Scandinavian Journal of Gastroenterology, 38(3), 283-287. https://doi.org/10.1080/00365520310000609a

Vancouver

Vainer B, Nielsen OH. Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis. Scandinavian Journal of Gastroenterology. 2003 mar 1;38(3):283-287. https://doi.org/10.1080/00365520310000609a

Author

Vainer, Ben ; Nielsen, O. Haagen. / Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis. I: Scandinavian Journal of Gastroenterology. 2003 ; Bind 38, Nr. 3. s. 283-287.

Bibtex

@article{bb61c96059014738a505b6ba9b19881a,
title = "Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis",
abstract = "Background: A soluble form of intercellular adhesion molecule-1 (sICAM-1) shed from endothelial cells is present in the circulation. Whether the circulating molecules represent passive turnover of surface ICAM-1 or may have some active functions in the inflammatory process is unknown. Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action. The aim of the present study was therefore to evaluate the ICAM-1-shedding through measurements of sICAM-1 concentrations during prednisolone treatment of UC patients. Methods: Prednisolone (40 mg) was prescribed to 15 patients with severe disease activity. At inclusion, and after 2 weeks of treatment, plasma sICAM-1 levels were measured using the ELISA technique. Results: The concentrations of sICAM-1 were significantly decreased during treatment from median 256.2 (ng/ml) (interquartile range 239.7-321.0 ng/ml) to 220.4 ng/ml (196.0-276.3 ng/ml) (P < 0.01). This reduction correlated with a decrease in disease activity (rs = 0.8; P < 0.003). Conclusions: sICAM-1 seems to be a poor diagnostic tool, but since plasma sICAM-1 concentrations decreased during the treatment period, it might prove to be applicable as an activity marker in the individual patient.",
keywords = "Cell adhesion molecules, Glucocorticoids, ICAM-1, Prednisolone, Ulcerative colitis",
author = "Ben Vainer and Nielsen, {O. Haagen}",
year = "2003",
month = "3",
day = "1",
doi = "10.1080/00365520310000609a",
language = "English",
volume = "38",
pages = "283--287",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Correlation between circulating soluble ICAM-1 and rednisolone-induced amelioration of ulcerative colitis

AU - Vainer, Ben

AU - Nielsen, O. Haagen

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background: A soluble form of intercellular adhesion molecule-1 (sICAM-1) shed from endothelial cells is present in the circulation. Whether the circulating molecules represent passive turnover of surface ICAM-1 or may have some active functions in the inflammatory process is unknown. Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action. The aim of the present study was therefore to evaluate the ICAM-1-shedding through measurements of sICAM-1 concentrations during prednisolone treatment of UC patients. Methods: Prednisolone (40 mg) was prescribed to 15 patients with severe disease activity. At inclusion, and after 2 weeks of treatment, plasma sICAM-1 levels were measured using the ELISA technique. Results: The concentrations of sICAM-1 were significantly decreased during treatment from median 256.2 (ng/ml) (interquartile range 239.7-321.0 ng/ml) to 220.4 ng/ml (196.0-276.3 ng/ml) (P < 0.01). This reduction correlated with a decrease in disease activity (rs = 0.8; P < 0.003). Conclusions: sICAM-1 seems to be a poor diagnostic tool, but since plasma sICAM-1 concentrations decreased during the treatment period, it might prove to be applicable as an activity marker in the individual patient.

AB - Background: A soluble form of intercellular adhesion molecule-1 (sICAM-1) shed from endothelial cells is present in the circulation. Whether the circulating molecules represent passive turnover of surface ICAM-1 or may have some active functions in the inflammatory process is unknown. Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action. The aim of the present study was therefore to evaluate the ICAM-1-shedding through measurements of sICAM-1 concentrations during prednisolone treatment of UC patients. Methods: Prednisolone (40 mg) was prescribed to 15 patients with severe disease activity. At inclusion, and after 2 weeks of treatment, plasma sICAM-1 levels were measured using the ELISA technique. Results: The concentrations of sICAM-1 were significantly decreased during treatment from median 256.2 (ng/ml) (interquartile range 239.7-321.0 ng/ml) to 220.4 ng/ml (196.0-276.3 ng/ml) (P < 0.01). This reduction correlated with a decrease in disease activity (rs = 0.8; P < 0.003). Conclusions: sICAM-1 seems to be a poor diagnostic tool, but since plasma sICAM-1 concentrations decreased during the treatment period, it might prove to be applicable as an activity marker in the individual patient.

KW - Cell adhesion molecules

KW - Glucocorticoids

KW - ICAM-1

KW - Prednisolone

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=0037363653&partnerID=8YFLogxK

U2 - 10.1080/00365520310000609a

DO - 10.1080/00365520310000609a

M3 - Journal article

C2 - 12737443

AN - SCOPUS:0037363653

VL - 38

SP - 283

EP - 287

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 3

ER -

ID: 218716122