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Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review

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A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression based on diagnostic measures and definition of p16 overexpression. We evaluated means of p16 and HPV diagnostics, and quantified overexpression of p16 in HPV-positive and -negative OP-SCCs by mode of immunohistochemical staining of carcinoma cells.
OriginalsprogEngelsk
TidsskriftB J C
Vol/bind110
Udgave nummer6
Sider (fra-til)1587-94
Antal sider8
ISSN0007-0920
DOI
StatusUdgivet - 18 mar. 2014

ID: 109650743