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Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

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Standard

Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. / Wu, Xingchen; Hanson, Lars Grüner; Skimminge, Arnold; Sorensen, Per Soelberg; Paulson, Olaf Bjarne; Mathiesen, Henrik Kahr; Blinkenberg, Morten.

I: Neurological Research, Bind 36, Nr. 8, 08.2014, s. 701-708.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Wu, X, Hanson, LG, Skimminge, A, Sorensen, PS, Paulson, OB, Mathiesen, HK & Blinkenberg, M 2014, 'Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis', Neurological Research, bind 36, nr. 8, s. 701-708. https://doi.org/10.1179/1743132813Y.0000000312

APA

Wu, X., Hanson, L. G., Skimminge, A., Sorensen, P. S., Paulson, O. B., Mathiesen, H. K., & Blinkenberg, M. (2014). Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurological Research, 36(8), 701-708. https://doi.org/10.1179/1743132813Y.0000000312

Vancouver

Wu X, Hanson LG, Skimminge A, Sorensen PS, Paulson OB, Mathiesen HK o.a. Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurological Research. 2014 aug;36(8):701-708. https://doi.org/10.1179/1743132813Y.0000000312

Author

Wu, Xingchen ; Hanson, Lars Grüner ; Skimminge, Arnold ; Sorensen, Per Soelberg ; Paulson, Olaf Bjarne ; Mathiesen, Henrik Kahr ; Blinkenberg, Morten. / Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. I: Neurological Research. 2014 ; Bind 36, Nr. 8. s. 701-708.

Bibtex

@article{1d3cbc800dd04efa9e6cc845a3db30a6,
title = "Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis",
abstract = "OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r  =  -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), but not with EDSS at year 7.DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.",
keywords = "Adult, Aspartic Acid, Cerebral Cortex, Creatine, Disability Evaluation, Disease Progression, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Multiple Sclerosis, Prognosis, Young Adult",
author = "Xingchen Wu and Hanson, {Lars Gr{\"u}ner} and Arnold Skimminge and Sorensen, {Per Soelberg} and Paulson, {Olaf Bjarne} and Mathiesen, {Henrik Kahr} and Morten Blinkenberg",
year = "2014",
month = "8",
doi = "10.1179/1743132813Y.0000000312",
language = "English",
volume = "36",
pages = "701--708",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Taylor & Francis",
number = "8",

}

RIS

TY - JOUR

T1 - Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

AU - Wu, Xingchen

AU - Hanson, Lars Grüner

AU - Skimminge, Arnold

AU - Sorensen, Per Soelberg

AU - Paulson, Olaf Bjarne

AU - Mathiesen, Henrik Kahr

AU - Blinkenberg, Morten

PY - 2014/8

Y1 - 2014/8

N2 - OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r  =  -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), but not with EDSS at year 7.DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.

AB - OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r  =  -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r  =  -0·61, P < 0·05), but not with EDSS at year 7.DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.

KW - Adult

KW - Aspartic Acid

KW - Cerebral Cortex

KW - Creatine

KW - Disability Evaluation

KW - Disease Progression

KW - Female

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Prognosis

KW - Young Adult

U2 - 10.1179/1743132813Y.0000000312

DO - 10.1179/1743132813Y.0000000312

M3 - Journal article

C2 - 24620975

VL - 36

SP - 701

EP - 708

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 8

ER -

ID: 137436316