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COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF). / Kopp, Katharina Luise Maria; Kauczok, C. S.; Lauenborg, Britt Thyssing; Krejsgaard, Thorbjørn Frej; Eriksen, Karsten Wessel Kam; Zhang, Q.; Wasik, M. A.; Geisler, Carsten; Ralfkiaer, Elisabeth Methner; Becker, J. C.; Ødum, Niels; Andersen, Anders Woetmann.

I: Leukemia, Bind 24, Nr. 6, 2010, s. 1179-1185.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kopp, KLM, Kauczok, CS, Lauenborg, BT, Krejsgaard, TF, Eriksen, KWK, Zhang, Q, Wasik, MA, Geisler, C, Ralfkiaer, EM, Becker, JC, Ødum, N & Andersen, AW 2010, 'COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF)', Leukemia, bind 24, nr. 6, s. 1179-1185. https://doi.org/10.1038/leu.2010.66

APA

Kopp, K. L. M., Kauczok, C. S., Lauenborg, B. T., Krejsgaard, T. F., Eriksen, K. W. K., Zhang, Q., Wasik, M. A., Geisler, C., Ralfkiaer, E. M., Becker, J. C., Ødum, N., & Andersen, A. W. (2010). COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF). Leukemia, 24(6), 1179-1185. https://doi.org/10.1038/leu.2010.66

Vancouver

Kopp KLM, Kauczok CS, Lauenborg BT, Krejsgaard TF, Eriksen KWK, Zhang Q o.a. COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF). Leukemia. 2010;24(6):1179-1185. https://doi.org/10.1038/leu.2010.66

Author

Kopp, Katharina Luise Maria ; Kauczok, C. S. ; Lauenborg, Britt Thyssing ; Krejsgaard, Thorbjørn Frej ; Eriksen, Karsten Wessel Kam ; Zhang, Q. ; Wasik, M. A. ; Geisler, Carsten ; Ralfkiaer, Elisabeth Methner ; Becker, J. C. ; Ødum, Niels ; Andersen, Anders Woetmann. / COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF). I: Leukemia. 2010 ; Bind 24, Nr. 6. s. 1179-1185.

Bibtex

@article{910e0910723a11df928f000ea68e967b,
title = "COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF)",
abstract = "Cancer often originates from a site of persistent inflammation, and the mechanisms turning chronic inflammation into a driving force of carcinogenesis are intensely investigated. Cyclooxygenase-2 (COX-2) is an inducible key modulator of inflammation that carries out the rate-limiting step in prostaglandin synthesis. Aberrant COX-2 expression and prostaglandin E(2) (PGE(2)) production have been implicated in tumorigenesis. In this study we show that COX-2 is ectopically expressed in malignant T-cell lines from patients with cutaneous T-cell lymphoma (CTCL) as well as in situ in lymphocytic cells in 21 out of 22 patients suffering from mycosis fungoides (MF) in plaque or tumor stage. COX-2 is not expressed in lymphocytes of 11 patients with patch-stage MF, whereas sporadic COX-2 staining of stromal cells is observed in the majority of patients. COX-2 expression correlates with a constitutive production of PGE(2) in malignant T cells in vitro. These cells express prostaglandin receptors EP3 and EP4 and the receptor antagonist as well as small interfering RNA (siRNA) directed against COX-2, and specific COX-2 inhibitors strongly reduce their spontaneous proliferation. In conclusion, our data indicate that COX-2 mediated PGE(2) exerts an effect as a tumor growth factor in MF.Leukemia advance online publication, 29 April 2010; doi:10.1038/leu.2010.66.",
author = "Kopp, {Katharina Luise Maria} and Kauczok, {C. S.} and Lauenborg, {Britt Thyssing} and Krejsgaard, {Thorbj{\o}rn Frej} and Eriksen, {Karsten Wessel Kam} and Q. Zhang and Wasik, {M. A.} and Carsten Geisler and Ralfkiaer, {Elisabeth Methner} and Becker, {J. C.} and Niels {\O}dum and Andersen, {Anders Woetmann}",
year = "2010",
doi = "10.1038/leu.2010.66",
language = "English",
volume = "24",
pages = "1179--1185",
journal = "Leukemia",
issn = "0887-6924",
publisher = "nature publishing group",
number = "6",

}

RIS

TY - JOUR

T1 - COX-2-dependent PGE2 acts as a growth factor in mycosis fungoides (MF)

AU - Kopp, Katharina Luise Maria

AU - Kauczok, C. S.

AU - Lauenborg, Britt Thyssing

AU - Krejsgaard, Thorbjørn Frej

AU - Eriksen, Karsten Wessel Kam

AU - Zhang, Q.

AU - Wasik, M. A.

AU - Geisler, Carsten

AU - Ralfkiaer, Elisabeth Methner

AU - Becker, J. C.

AU - Ødum, Niels

AU - Andersen, Anders Woetmann

PY - 2010

Y1 - 2010

N2 - Cancer often originates from a site of persistent inflammation, and the mechanisms turning chronic inflammation into a driving force of carcinogenesis are intensely investigated. Cyclooxygenase-2 (COX-2) is an inducible key modulator of inflammation that carries out the rate-limiting step in prostaglandin synthesis. Aberrant COX-2 expression and prostaglandin E(2) (PGE(2)) production have been implicated in tumorigenesis. In this study we show that COX-2 is ectopically expressed in malignant T-cell lines from patients with cutaneous T-cell lymphoma (CTCL) as well as in situ in lymphocytic cells in 21 out of 22 patients suffering from mycosis fungoides (MF) in plaque or tumor stage. COX-2 is not expressed in lymphocytes of 11 patients with patch-stage MF, whereas sporadic COX-2 staining of stromal cells is observed in the majority of patients. COX-2 expression correlates with a constitutive production of PGE(2) in malignant T cells in vitro. These cells express prostaglandin receptors EP3 and EP4 and the receptor antagonist as well as small interfering RNA (siRNA) directed against COX-2, and specific COX-2 inhibitors strongly reduce their spontaneous proliferation. In conclusion, our data indicate that COX-2 mediated PGE(2) exerts an effect as a tumor growth factor in MF.Leukemia advance online publication, 29 April 2010; doi:10.1038/leu.2010.66.

AB - Cancer often originates from a site of persistent inflammation, and the mechanisms turning chronic inflammation into a driving force of carcinogenesis are intensely investigated. Cyclooxygenase-2 (COX-2) is an inducible key modulator of inflammation that carries out the rate-limiting step in prostaglandin synthesis. Aberrant COX-2 expression and prostaglandin E(2) (PGE(2)) production have been implicated in tumorigenesis. In this study we show that COX-2 is ectopically expressed in malignant T-cell lines from patients with cutaneous T-cell lymphoma (CTCL) as well as in situ in lymphocytic cells in 21 out of 22 patients suffering from mycosis fungoides (MF) in plaque or tumor stage. COX-2 is not expressed in lymphocytes of 11 patients with patch-stage MF, whereas sporadic COX-2 staining of stromal cells is observed in the majority of patients. COX-2 expression correlates with a constitutive production of PGE(2) in malignant T cells in vitro. These cells express prostaglandin receptors EP3 and EP4 and the receptor antagonist as well as small interfering RNA (siRNA) directed against COX-2, and specific COX-2 inhibitors strongly reduce their spontaneous proliferation. In conclusion, our data indicate that COX-2 mediated PGE(2) exerts an effect as a tumor growth factor in MF.Leukemia advance online publication, 29 April 2010; doi:10.1038/leu.2010.66.

U2 - 10.1038/leu.2010.66

DO - 10.1038/leu.2010.66

M3 - Journal article

C2 - 20428208

VL - 24

SP - 1179

EP - 1185

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 6

ER -

ID: 20172260