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Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • Trong Tuan Dao
  • Ho Keun Won
  • Eun Hee Kim
  • Junsoo Park
  • Boo Yeon Won
  • Won Keun Oh
The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1–3) and 10 known (4−13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.
OriginalsprogEngelsk
TidsskriftFood Chemistry
Vol/bindVolume 134
Udgave nummerIssue 1
Sider (fra-til)21–28
ISSN0308-8146
StatusUdgivet - 1 dec. 2012

ID: 169014458