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Cytokines and soluble tumour necrosis factor I receptor levels during pretransplant conditioning in allogeneic stem-cell transplantation

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  • Johnny Andersen
  • Carsten Heilmann
  • Niels Jacobsen
  • Klaus Bendtzen
  • Klaus Müller
The inflammatory response induced by the conditioning regime may be related to the outcome in allogeneic stem-cell transplantation (SCT). However, previous statements concerning the prognostic significance of cytokine measurements during conditioning have not been conclusive. We investigated a broad range of cytokines in plasma samples drawn daily immediately before start of pretransplant conditioning and during the conditioning. The presented data indicate that single-day measurements of inflammatory cytokines during conditioning may lead to unreliable conclusions concerning their prognostic significance. However, serial quantitation of soluble tumour necrosis factor receptor I (sTNFRI) is more likely to reflect the degree of inflammatory activation induced by pretransplant conditioning.
OriginalsprogEngelsk
TidsskriftInternational Immunopharmacology
Vol/bind5
Udgave nummer1
Sider (fra-til)67-71
Antal sider5
ISSN1567-5769
DOI
StatusUdgivet - 1 jan. 2005

ID: 34102231