Forskning ved Københavns Universitet - Københavns Universitet

Forside

De Novo Pathway Enrichment with KeyPathwayMiner

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Biomolecular networks such as protein–protein interaction networks provide a static picture of the interplay of genes and their products, and, consequently, they fail to capture dynamic changes taking place during the development of complex diseases. KeyPathwayMiner is a software platform designed to fill this gap by integrating previous knowledge captured in molecular interaction networks with OMICS datasets (DNA microarrays, RNA sequencing, genome-wide methylation studies, etc.) to extract connected subnetworks with a high number of deregulated genes. This protocol describes how to use KeyPathwayMiner for integrated analysis of multi-omics datasets in the network analysis tool Cytoscape and in a stand-alone web application available at https://keypathwayminer.compbio.sdu.dk.

OriginalsprogEngelsk
TitelProtein-Protein Interaction Networks : Methods and Protocols
RedaktørerStefan Canzar, Francisca Rojas Ringeling
Antal sider19
ForlagHumana Press
Publikationsdato2020
Sider181-199
Kapitel14
ISBN (Trykt)978-1-4939-9872-2
ISBN (Elektronisk)978-1-4939-9873-9
DOI
StatusUdgivet - 2020
NavnMethods in Molecular Biology
Vol/bind2074
ISSN1064-3745

ID: 230742618